Prevalence and associated factors for kidney dysfunction in hospitalized patients with COVID-19 pneumonia in Zambia
Medical Journal of Zambia
; 49(1): 34-41, 2022. figures, tables
Article
in English
| AIM
| ID: biblio-1381701
Responsible library:
CG1.1
ABSTRACT
Abstract Background:
A significant link has been reported between COVID-19 pneumonia, disease severity and development of kidney dysfunction. This study assessed the prevalence and correlated factors for kidney impairment in hospitalized patients with COVID-19 infectionMethods:
This nested retrospective study examined medical files of patients with confirmed COVID-19 pneumonia. The outcome variable was kidney dysfunction ( defined as functional renal indexes beyond the normal range) and associated factors. Multivariate logistic regression was employed to establish factors associated with renal dysfunction.Results:
179 patients were included in this nested study and the mean age was 58.3 years (SD 16.5) and 49.0% were female. The prevalence of renal dysfunction was 51.9% and 39.3% these patients renal had eGFR<60 mL/min/1.73m2 The proportion of kidney impairment was higher in males than females (59.3% vs.44.3 %), patients with underlying hypertension than normotensive (60.5% vs. 39.5 %) and those with chronic kidney disease (CKD) than those without (90% vs. 10%). After adjusting for age, male gender, critical COVID-19 disease, and raised white cell count, hypertension was an independent predictor of kidney impairment with a AOR 1.54 (95% CI [1.06-2.23],p=0.022). Presence of HIV or diabetes mellitus showed a non statistical significance with renal dysfunction.Conclusion:
The study demonstrated a high prevalence of kidney dysfunction in hospitalized patients with COVID-19 pneumonia and presence of hypertension predicted nearly 2-fold development renal impairment.
Full text:
Available
Index:
AIM (Africa)
Main subject:
Acute Kidney Injury
/
COVID-19
/
Kidney Failure, Chronic
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Medical Journal of Zambia
Year:
2022
Type:
Article
Institution/Affiliation country:
Ndola Teaching Hospital/ZM
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