Pattern of liver enzymes and maternal outcome in eclamptic patients admitted to the Intensive Care Unit, University College Hospital, Nigeria
South Sudan med. j. (Online)
; 16(3)2023. figures, tables
Article
in English
| AIM
| ID: biblio-1452137
Responsible library:
CG1.1
ABSTRACT
Introduction:
Eclampsia, a hypertensive disorder, is one of the leading causes of maternal mortality in developing countries like Nigeria. We evaluated the relationship between the pattern of liver enzymes and maternal mortality in eclamptic women.Method:
A retrospective study of 55 eclamptic women admitted to the Intensive Care Unit (ICU), University College Hospital, Nigeria, was conducted. Data were obtained on their demographic, obstetric, and clinical characteristics, liver enzyme patterns, and maternal outcome. Analysis was by descriptive statistics, univariate analysis, and non-parametric tests with level of significance set at p<0.05.Results:
Maternal deaths occurred in 27.3% and elevation of liver enzymes was observed more among the dead patients compared with those who survived. Alanine aminotransferase (ALT) was the most commonly elevated liver enzyme, occurring in almost all (90.9%) the patients. Maternal mortality was significantly associated with age (p=0.001), saturated oxygen levels (p=0.007), elevated alkaline phosphatase (p=0.008), alanine aminotransferase (p=0.013), aspartate aminotransferase (p=0.016), and total bilirubin (p<0.001).Conclusion:
Maternal mortality due to eclampsia was clinically associated with age, elevated liver enzymes and a lower serum level of total bilirubin. Liver transaminases are therefore important prognostic indicators associated with eclampsia.Subject(s)
Full text:
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Index:
AIM (Africa)
Main subject:
Critical Care
/
Pregnant Women
/
Eclampsia
/
Enzymes
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
South Sudan med. j. (Online)
Year:
2023
Type:
Article
Institution/Affiliation country:
University College Hospital, Nigeria+NG
/
University College Hospital, Nigeria+NG
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