cardiovascular effects of oxodipine a new calcium antagonist compound in the anesthezied dog

The cardiovascular effects of oxodipine, a new calcium antagonist compound have been investigated in 30 anesthetized dog [pentobarbital 25 mg kg[-1] I.V.]. Heart rate and arterial pressure were continuously monitored. Oxodipine injected at 10, 15 and 75 mcg kg[-1] produces a significant hypotensive without change in heart rate. The L D 100 of oxodipine was determined by perfusion at rate of 75 mcg kg[-1], that of nifedipine at rate of 40 mcg kg[-1] min[-1]. Oxodipine appears as active as infedipine. The two compound present a structural analogy and the similar pharmacological profile of antihypertensive type, by predominant arterial action

Pharmacology and therapeutic use of antiarythmic drugs

In the last few years several new antiarrhythmics have been marketted joining the old cardiac rhythm trouble correctors already in existence for a several decades, such as quinidine and procainamide. Indisputable progress in two ways, effeictiveness and safety have been achieved. However there is still no ideal antiarrhythmic effective in all arrhythmia, which can be taken daily and with no serious side effects. But may be this is simply a utopian idea

Interest of dosage of theophyllinemia in bronchial asthma and adaptation of an efficient dosage

In 54 asthmatic patients, we assessed the interest of a simple protocol to adapt an efficient dosage of theophylline. Each patient has received a standard dose of 10 per Kg of ideal weight every 24 hours, distributed in 3 doses. The blood sample of theophylline is realized at the 48 th hours. 94.44% of patients accept the therapeutic regiment adopted after adjustement of their posologie for 20 cases

Can the amrinone struggle against myocardial depression induced by propanolol in narcotized dog

In the anesthetic dog, it has been researched if the amrinone, new positive inotropic agent, was able to face or to correct the depressor effect induced by propranolol. Used by simultanous perfusion to propranolol at the dose of 100 ug. Kg[-1], the amrinone increases significantly the LD 100 of propranolol from 33.4 +/- 2 mg. Kg[-1] to 44.14 +/- 4.21 mg. Kg[-1] and to 53.9 +/- 12.2 mg Kg[-1] at the dose of 300 ug. Kg[-1]. After the systolic arterial pressure reduction of 50 to 60% by the propranolol, perfusion of 25 or 50 ug. kg of amrinone correct quickly and completely the tensional decrease. The amrinone seems as a therapeutics not without interest in case of cardiovascular collapse induced by adrenergie betablocking agent