Environmental exposure to asbestos and the exposure-response relationship with mesothelioma

An epidemiological and environmental study was carried out in Shubra El-Kheima city, greater Cairo, of the exposure-response relationship between asbestos and malignant pleural mesothelioma. Radiological screening was done for 487 people occupationally exposed to asbestos, 2913 environmentally exposed to asbestos and a control group of 979 with no history of exposure. Pleural biopsy was done for suspicious cases. The airborne asbestos fibre concentrations were determined in all areas. There were 88 cases of mesothelioma diagnosed, 87 in the exposed group. The risk of mesothelioma was higher in the environmentally exposed group than other groups, and higher in females than males. The prevalence of mesothelioma increased with increased cumulative exposure to asbestos

Effect of Omeprazole [a protein pump inhibitor] on exocrine pancreatic secretion in dogs

The results concluded that there is a competitive inhibition between [omeprazole] and secretin or insulin at the receptor site, interference of omeprazole with the activity of adenylate cyclase enzyme and therefore, blocking formation of cAMP, so interferes with the section of secretion hormone and inhibition of ATPase enzyme activity of omeprazole specially Na+-H+ ATPase for secretin action or Na+-K+ ATPase for insulin action. Therefore, further investigations are needed to clarify the subcellular mechanisms of omeprazole which are responsible for its inhibitory action on stimulated exocrine pancreatic secretion