May the dose of suxamethonium influence the subsequent muscle pain and damage

In 45 healthy, ASA 1 and 11 patients aging from 20 - 60 years, undergoing Short moderate or a day-case surgery they were randomly allocated to receive one of three doses of succinyl choline; 0.5,1.5 and 2.5 mg/Kg. The induction and maintenance was carried out by the conventional methods of anaesthesia. We observed the severity of fasciculations and examined postoperative muscle pains changes in serum concentrations of myoglobin and serum calcium and potassium as a sign of muscle damage following administration of succinyl choline.The incidence and severity of fasciculations and post-operative muscle pains were greater in group II [1.5 mg/Kg suxamethonium], than in group I [0.5 mg/Kg] and group III [2.5 mg/Kg], The serum concentrations of myoglobin increased in a dose-related pattern, changes in serum concentrations of calcium and potassium were minimal and nearly the same in the 3 groups of patients. Intubating conditions were significamly [P < 0.05] better in group III receiving 2.5 mg/Kg. succinylcholine than in group I and II receiving 0.5 and 1.5 mg/Kg respectively. These results suggest that larger dose of suxamethonium [2.5 mg/Kg] provided a better intubating conditions, less fasciculations, minimal postoperative muscle pains with no bad influence in electrolyte and serum myoglobin

effect of induction agent diprivan on intraocular pressure in comparison with thiopentone

Propofol [Diprivan] has been used as an induction agent to reduce and control, the intraocular pressure in 21 patients of both sexes [16 males and 5 females] ranging in age from 18 - 66 years. They were undergoing elective ophthalmic surgery. Its effects have been compared with 20 patients induced with thiopentone. The effect of suxamethonium and intubation on IOP were studied in the two groups of patients using applanation tonometer. Diprivan proved to be a very satisfactory agent that produce a significant fall in IOP and was significantly more effective than thiopentone in this respect. Also propofol attenuate the increase in IOP before intubation and appear to be the drug of choice in ophthalmic surgery which required smooth induction of anaesthesia and effective control of IOP