New treatment of hyperemesis gravid arum a randomized study

A randomized study was undertaken to assess efficacy of micronizedprogesterone as a new treatment ofhyperemesis gravidarum compared with anti-emetics, anti-histaminics, liver support, vitamin B6 and intravenousfluids.The study was conducted on 40 pregnant ladies diagnosed as hyperemesis gravidarum. They wererandomized into 2 groups:Group [I] includes twenty cases where intravenous fluids [5-6 L], sodium bicarbonate, liver support, vitamin B6,anti-emetics and anti-histaminics were given.Group [II] includes twenty cases were treated with micronized progesterone, intravenous fluids and sodiumbicarbonate were given.Both groups were subjected to complete blood picture [CBP], liver and kidney function tests, serum sodium [Na] and potassium [K], serum estrogen and progesterone estimations.This study indicated that significant differences were found on both groups between CBP, liver and kidneyfunction tests, serum Na and K levels, serum estrogen and progesterone levels after treatment than before.Signiflcnt differences were found between the two groups after treatment as regard kidney and liver function testsand also, seum progesterone levels.Intavenous fluid hydration and electrolytes correction is essential in the management of hyperemesisgravidarum. Micronized progesterone is an effective therapy as anti-emetics, anti histaminics, vitamin B6 and liversupport in controlling hyperemesis gravidarum

Role of Omega-3 essential fatty acids in pregnancy induced hypertension

Pre-eclampsia is a major health problem contributig largely to maternal and neonatal morbidity and mortality which is of obscure etiology. It is characterized by vasoconstriction and platelet aggregation which is attributed to imbalance of thromboxane A2 and prostacyclin A2. This imbalance could be corrected by polyunsaturated fatty acids of n-3 class by competing with arachidonic acid for cyclooxygenase enzyme producing inactive prostanoid. To study the relation of omega-3 fatty acids and the severity of pre-eclampsia. 10 mild pre-eclamptic, 10 severe pre-eclamptic and 10 eclamptic patients were compared to a control group of 20 normal pregnant patients for their plasma levels of omega-3 fatty acids using high performance liquid chromatography. pre-eclamptic patients were significantly lower in their plasma levels of fatty acids than in control group

Comparison of direct immunofluorescence [DIF] and enzyme immunoassay [ELISA] for detection of chlamydia trachomatis infection in cases of abortion and premature rupture of membrane

Genital Chlamydia trachomatis [C. trachomatis] in the endocervix was investigated among 90 pregnant women [60 women applying for spontaneous abortion and 30 women with premature rupture of membrane [PROM]; The incidence of infection with this sexual transmitted pathogen was 1.67% among asymptomatic low risk group and 23.33% among the group presenting with symptomatic endocervitis [high risk group] with a total incidence among the 90 pregnant women of 8.89%. C. trachomatis was found more associated with greater sexual activity so it's incidence was high among younger age group and early marriage. The diagnosis of genital C. trachomatis was done by non culture immunological detection of Chlamydial antigens. We applied tuo different methods for diagnosis, direct immunofluorescence and enzyme immunoassay. The sensitivity and specificity of DIF in our study was 88.89% and 100% respectively while the sensitivity of ELISA was more than DIF [100%] and the specificity was slightly lower [98.7%]. The percentage of over all agreement between the two antigen detection assays were 98.8%. Neither test is ideal for diagnosis of Chlamydial infection but still they can provide an alternative to the cost, time consuming and technique dependent cell culture. The effect of C. trachomatis on the outcome of pregnancy is still speculative. There is a significant [P<0.05] association between spontaneous abortion and endocervical carriage of Chlamydia. Other adverse pregnancy outcomes as PROM were not associated with Chlamydia positive women