Fibrin degradation products [FDP] in urinary bladder transitional cell carcinoma [TCC] as a marker of its invasiveness

Urinary FDPs were estimated in 15 patients with superficial TCC, 15 patients with deep TCC and in 10 healthy controls. Significantly higher FDPs levels were detected in the tumor group. FDPs in deep tumors were significantly higher than in superficial ones. The FDPs level showed a positive correlation with tumor grade and stage. Comparison between FDPs and urine cytology displayed better sensitivity for FDPs in tumor diagnosis. FDPs may be used as a marker of tumor invasiveness

HLA pattern in Squamous Cell Carcinoma [SCC] of the schistosomal urinary bladder

Histocompatibility antigens [HLA-A and B] were studied in 38 patients with squamous cell carcinoma [SCC] of the sch. urinary bladder and 300 control healthy individuals. No significant increase in HLA antigens frequencies were detected. The relative risk in the studied patients with SCC was not significantly different from the control. However, the genetic role in bladder carcinoma should be pursued by studying the HLA D and Dr loci antigens

Acid-base status and electrolyte shifts during transuretheral resection of the prostate

Metabolic changes underlying TURP have not yet been fully investigated. This attracted attention to investigate both the electrolyte and acid-base shifts after TURP in 39 patients. They were divided into two groups according to the use of either distilled water or glycine 1.5% for irrigation during the procedure. Nalbuphine was given for premedication and carbocaine 4% for spinal analgesia. During surgery, ECG, HR and BP were monitored; while serum electrolytes and acid-base data were determined pre- and postoperatively. Significant degrees of hyponatremia have characterized the use of either irrigating solution. Nonsignificant rise of serum potassium followed distilled water irrigation. More metabolic acidosis took place with glycine irrigation. TUR syndrome was diagnosed in one patient with glycine irrigation and was properly treated. It was concluded that the search for an irrigation solution with closer properties to ideality is m and atory. Important practical points for anaesthesia and surgery during TURP were recommended for consideration