affinity of hemoglobin and its components to lead, in occupationally exposed workers

The present study was carried out on 225 workers occupationally exposed to lead in the printing industry. Blood-lead concentration was measured by atomic absorption spectroscopy. The level increased with the severity of the toxicity. Chromatographic separation followed by determination of lead concentration, showed that fetal hemoglobin [HbF] possesses a higher affinity to lead than HbA and HbA2. B-chain represented the main lead receptor of adult hemoglobin [HbA]. While, alpha-globin of fetal origin had a higher affinity for lead. Viscosity and conductivity of Hb were increased with blood-lead elevation

Curative effect of bone marrow transplantation on irradiated liver and plasma proteins

The histopathological examination of mice liver exposed to whole body gamma irradiation [6 Gy] followed by bone marrow transplantation [BMT], showed a moderate degree of recovery after 20 days. Parallel electrophoretic analysis of plasma proteins revealed significant increase only in alpha and gamma-globulins. Accordingly, it could be assumed that BMT ameliorated partially the liver histopathology and the level of certain plasma proteins after 20 days, so it could be considered as a convenient therapy following whole body gamma- irradiation