ABSTRACT
The formation of novel annulated and annelated heterocyles rings is an important task for heterocyclic chemists from various points of view. Furthermore, many condensed heterocyclic systems especially when linked to pyrimidine ring, play an important role as analgesic [1], antihypertensive [2], antipyretic and anti-inflammatory drugs [4], also as pesticides [5], herbicides[6] and plant growth regulator [7] In addition, the pyrido[2, 3-d]pyrimidine ring system is of biological interest due to the relationship between this ring and purine which is an essential part of DNA and RNA, the first is the molecule responsible for the storage of genetic information and the latter is prominently involved in the synthesis of enzymes. In continuation of our work[8, 9] aimed at developing new approachs for the synthesis of some new pyridopyrimidine products with expected biological activity
Subject(s)
Pyrimidines/chemical synthesis , Anti-Infective Agents , AnalgesicsABSTRACT
Avariety of pyrimidine derivatives 2-4 and annulated pyrimidine derivatives 5-17 have been synthesized via a sequence of heterocyclization reactions of readily available 6-naphthyl-4-oxo-2-thioxo- 1, 2, 3, 4-tetrahydroprimidine-5-carbonitrile [1] with different acidic and basic reagents. The new compounds were synthesized with the aim of studying their antimicrobial activity. The structures of all synthesized compounds were elucidated by elemental analysis and spectroscopic studies
Subject(s)
Anti-Infective Agents , Spectrum AnalysisABSTRACT
Pyrimidine derivatives have attracted considerable interest in the recent years. Their derivatives have been known to display a wide range of pharmacological activities[1-8] such as antitumor, antioxidants, antiviral, antifungal and hepatoprotective activities. Prompted by these facts, and as a continuation of the previous work [9,10] on synthesis of biologically active heterocyclic compounds, we report in this investigation on the preparation of new series of biologically active pyrimidine derivatives