Becker's nevus with ipsilateral breast hypoplasia: a case report and review of literature

Specific cutaneous associations in patients with Becker's nevus have been reported. We present a patient with typical clinical and histopathological features clearly consistent with Becker's nevus associated with ipsilateral breast hypoplasia. The changes were distinct and could be separated from smooth muscle hamartoma. We include clinical and histological illustrations of our case.

Uses of intravenous immunoglobulines

Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathic thrombocytopenic purpura. IVIg treatment has been shown to be safe, without many drug-related adverse effects, including systemic immunosuppression, that are related to corticosteroids and other immunosuppressive agents. Current dermatologic uses of IVIg are increasing, which calls for adequately controlled clinical trials. This review evaluates the current published data on the use of IVIg therapy in the treatment of autoimmune diseases and discusses current opinion concerning its potential immunomodulating mechanisms, the industrial preparation and safety features of this biologic agent

Fixed drug eruption: a descriptive study of 100 cases

Fixed drug eruption [FDE] is one kind of drug rashes that is characterized by re-appearance of the lesions on the same sites after re-exposure to the causative drug. This study was performed to evaluate the epidemiologic characteristics of FDE. This descriptive study was done on a series of 100 FDE cases, who were admitted at the outpatient dermatology clinic of Hazrat-e-Rasoul Hospital over a six-year period. The primary diagnosis of FDE was suggested according to clinical findings including a remaining hyperpigmentation at the site of healed skin lesion [s]. Oral challenge test with a single low dose administration of the suspected drug was used to confirm the diagnosis. Recurrence of the lesion [s] at the same body area [s] was considered as positive result. Most commonly causative agents were co-trimoxazole and codein, which were found in 88% and 3% FDE cases; respectively. The most common site of involvement was penile glans in 57.7% of male patients and trunk in 48.3% of females. In one patient, reaction to multiple drugs including co-trimoxazole, codein and tetracycline was observed and after re-challenge with each drug, re-appearance of the skin lesion at the same site was evident. Several patients reported concomitant acetaminophen intake, but there was no reaction to that drug. Co-trimoxazole is the most common cause of FDE

Recurrent local palmar peeling associated with port-wine stain

There are no reports of association of specific cutaneous conditions in patients with local recurrent palmar peeling. Herein, we report a case with characteristic clinical presentation of local recurrent palmar peeling associated with a port-wine stain lesion.To the best of our knowledge, that association has not been reported before. Interesting points in the presented case are unilateral occurrence of the peeling disorder and its limitation to the region of port-wine stain

[Circumscribed juvenile pityriasisrubrapilaris associated with hypoparathyroidism and brachyonychia: a case report]

Circumscribed juvenile pityriasisrubrapilaris[PRP] is a form of PRP that manifests with well-defined erythematous scaly plaques with follicular keratosis mainly over knees and elbows. There are several reports of the association of PRP with other conditions. We report a boy with scattered erythematosquamous skin lesions and follicular hyperkeratotic papules since the age of six years. Skin biopsy was compatible with PRP. He also had hypoparathyroidism and brachyonychia. To our knowledge, this association has not been reported so far