Evaluation of the effect of estrogen and progesterone at different doses on the major salivary glands of rat

An evaluative study of the effect of different doses of estrogen andprogesterone, either singly or in combination, for 21 days was undertaken on the major salivary glands of female rats. Variable degrees of acinar atrophy in submandibular and parotid glands occurred whether estrogen and progesterone were administered individually or in combination. The most severe acinar atrophy occurred when the low doses of both hormones were combined. Conversely, sublingual acini became hypertrophic individually or in combination at the same individually given doses. While, an eventual degeneration of tubules was associated more with estrogen than with progesterone; it was most extensive when 2.1 mg progesterone was combined with a moderate dose of 0.021 mg estrogen. However, the tubules showed hormonally induced initial proliferation. The content of the acidic mucins was unchanged in parotid and submandibular glands. Conversely, this content in sublingual gland was increased with estrogen and decreased with progesterone administration

Histological changes of the dental pulp of rat after estrogen and progesterone administration

In response to the parental administration of estrogen and/or progesterone, atdifferent doses, the pulp showed dramatic regressive alterations which couldbe categorized into; edematous vacuolization of the odontoblastema associatedwith the displacement of odontoblasts and their nuclei, and the elaboration ofnodular or diffused vascularized tissue hyperplasia. The individualadministration of estrogen produced more generous pulp regression than thatshowed with progesterone. The regressive effects of the individualadministration of either of these hormones were more or less dramaticallyreversed when both of them were simultaneously administered. Theantiestrogenic potentiality of progesterone to control the unrestrainedpernicious influences of estrogen on the pulp tissue was highly determinedwhen administered in combination with estrogen only at a properproportional measures. However, it seems that the presence of both hormonesin a symbiotic condition would be essential for the maintenance and integrityof the normal structure of the dentin-pulp complex

study of the histology and carbohydrate histochemistry of the posterior lingual and palatine salivary glands of rat after estrogen and progesterone administration

An investigation of the effect of daily intramuscular administration ofestrogen and/or progesterone, for 21 days at different doses, has beenperformed on female rats to study the histological and histochemicalparticulars of the posterior lingual and palatine glands after hormonization. On the other hand, the increase in acidic mucin when 2.1 mg progesterone iscombined with high estrogen dose, indicates that the antiestrogenic effect ofprogesterone is highly blocked with the increase of estrogen dose