Athens-like G6PD variant associated with chronic non-spherocytic hemolytic anemia found in Jordan

A G6PD variant associated with hereditary non-spherocytic hemolytic anemia is characterized. The variant which closely resembles Athens-like variant was found in a male member of a family of Palestinian origin. The enzymatic properties were; normal electrophoretic mobility, normal Km NADP + low Km G6PD, increased utilization of substrate analogues, moderate heat stability, and a biphasic pH curve with two peaks at pH 7.0 and 10.0.Athens-like variants resemble the Mediterranean variant of G6PD but can be readily distinguished by the rate of utilization of the substrate analogue deamino-NADP + [about twice less]

role of surgery in rhabdomyosarcoma of the ear

Two cases of Rhabdomyosarcoma of the ear are reported. The tumor was localized to the ear In one, and the patient was treated by chemotherapy and radiotherapy. The second had metastases in the neck in addition to ear involvement and was treated with Chemotherapy, Radiotherapy, Radical Mastoidectomy and Radical neck dissection. Both patients are well and alive for more than 5 years. We believe that surgery in addition to chemotherapy and radiotherapy may improve the prognosis