ABSTRACT
Background: Cardiovascular diseases [CVD] is the leading cause of death in patients with type 2 diabetes accounting for 50-70% of all deaths [Berryet al., 2007] and it is believed that in 2020 CVD over-run infectious diseases and cancer to become the leading cause of death and disability, so the evidence is accumulating in favor of a wider use of several novel biomarkers in CVD [Dotsenko et al., 2007]
Aim of the work: 1- Evaluation of plasma BNP, hs-CRP and microalbuminuria as a risk biomarkers in detection of left ventricular diastolic dysfunction [LVDD], low ABI and increase in carotid intima- media thickness [CIMT] in asymptomatic type 2 diabetic female patients. 2- Detection of LVDD, peripheral arterial disease and carotid lesion in asymptomatic type 2 diabetic female patients in comparison to controls and their relation to cardiovascular risk biomarkers
Patients and methods: The study included 50 type 2 diabetic female patients [patient group] with duration of diabetes from 5-7 years and another age matched 40 female subjects were chosen as [control group]. Patients and controls were subjected to the following: history taking, body mass index [BMI], waist circumference, electrocardiography, echocardiography, ankle brachial index [ABI] and carotid duplex and laboratory investigations including; blood glucose, lipogram, serum creatinine, hemoglobin A1c [HbA1c,], BNP, hs -CRP and microalbuminuria
Results: -BNP, CRP and ,microalhuminuria significantly increased [P=0. 000] in diabetic patients versus controls. -There was significant LVDD, low ABJ and significant increase in CIMT in diabetic patients versus controls - Significant increase in BNP, CRP and microalbuminuria in patients having LVDD, low and in patients having increase in CIMT There was a significant positive correlation between diastolic dysfunction and CIMT with BNP, also there was significant negative correlation between ABI and BNP as a cardiovascular predictor at [p<0.05] with [r-square] [0. 778, 0.350 and 0.282] respectively
Conclusions: BNP, CRP and microalbuminuria are significant cardiovascular biomarkers in type 2 diabetic finale patients. BNP is a significant cardiovascular predictor for LVDD, low ABI and increase in CIMT