ABSTRACT
Aims: To investigate the constituents and antimicrobial activity of essential oil from Vitex negundo seeds. Study Design: The essential oil of Vitex negundo seeds was prepared by hydrodistillation. GC/MS technique was used to determine the volatile constituents in the oil. A total of 13 isolates of bacteria and fungi were employed to evaluate the antimicrobial activity of the oil. Place and Duration of Study: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, between April 2010 and September 2010. Methodology: Essential oil from Vitex negundo seeds were obtained by hydrodistillation, with constituents analyzed by GC-MS. Antimicrobial activity of the oil was evaluated against both Gram-positive and Gram-negative bacteria and fungi. Results: A total of forty-two components, representing 91.36% of the oil, were identified. n-Hexadecanoic acid (17.68%), eudesm-4(14)-en-11-ol (12.39%) and caryophyllene oxide (10.79%) were found to be the major constituents. The essential oil exhibited significant antifungal activity against Candida albicans at MIC 4.0 μg/ml. Conclusion: The essential oil of Vitex negundo seeds showed potential antifungal activity and can be of potential use in pharmaceutical fields.
ABSTRACT
<p><b>OBJECTIVE</b>To report the results of curative and adverse effects of compound huangdai tablet (CHDT) as induction therapy for 193 patients with acute promyelocytic leukemia (APL).</p><p><b>METHODS</b>CHDT was administered 1.25 g orally three times a day after meal for three days, then the dosage was gradually increased to 7.5 g/d.</p><p><b>RESULTS</b>One hundred and ninety-three patients achieved complete remission (CR), 78.8% of whom in 30 to 60 days with an average time of 44.3 d. No serious infection, bleeding or DIC occurred during the treatment course. The major adverse effects were gastrointestinal symptoms. There was no change in lanine transaminase, urea, creatinine or electrocardiographic QTc interval in 110 APL patients observed before and after the treatment.</p><p><b>CONCLUSION</b>CHDT therapy is a modality of higher CR rate, good safety and tolerance without bone marrow suppression for APL patients.</p>