ABSTRACT
Dyskinesia is one kind of motor complications caused by prolonged administration of levodopa to patients affected by Parkinson's disease. The mechanisms of dyskinesia in Parkinson's disease are still unknown. Recent research suggests the prevalence of dyskinesia mainly depends on genetic factors, levodopa therapy,clinical subtype, body weight and gender. Accumulating evidence indicates that assessment scales, functional magnetic resonance imaging and biomarkers could improve the clinical diagnosis and assessment of dyskinesia. In addition, a number of clinical trials of dyskinesia have indicated that new drugs such as an extended-release formulation of adamantine, and physical therapy such as repetitive transcranial magnetic stimulation are beneficial to the treatment of dyskinesia.
ABSTRACT
Objective To establish the characteristic spectrum of ginkgo leaf tablets,ginkgo leaf capsules,and ginkgo leaf dropping pills.Methods HPLC-ELSD analysis was performed on an Agilent Poroshell 120 EC-C18 column(150 mm×4.6 mm,2.7 μm)with the methanol-0.1% formic acid as mobile phase at the gradient elution mode,flow rate was 0.8 mL·min-1.Results Referring to the reference extract,a total of 12 peaks were established in the characteristic spectrum and selected as the characteristic common peaks.Conclusion The established method was simple and sensitive with good reproducibility,so it could be used to control the quality of ginkgo leaf preparations.