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Objective:To compare the adverse reactions for patients with brain tumor before and after gamma knife treatment, and analyze the application effect about pertinency nursing intervention measures.Methods: From January 2015 to February 2016, 80 patients with brain tumor who were treated by gamma knife were divided in observation group (40 cases, received pertinency nursing) and control group(40 cases, received normal nursing intervention) with random number table. And to compare the nursing effect difference between the two goups.Results: The average intracranial pressure of the two groups was (186.4±34.2)mmH2O before treatment; it was (232.3±41.5)mmH2O after treatment; and the difference was statistical significant (t=7.634,P=7.634). The observation group were lower than control group in epilepsy, scalp rupture and scalp infection rate, and the difference was statistical significant(x2=4.211,x2=5.541,x2=3.914;P<0.05). The average intracranial pressure and recovery time of observation group were (195.3±36.9)mm H2O and (13.4±3.2)d, respectively, after treatment. Both of the two indexes were lower than (218.2±42.5) mmH2O and (16.1±3.7)d of control group, and the difference was statistical significant(t=2.573, t=3.491;P<0.05). The observation group were lower than control group in occurrence rates of headache, vomiting and papilledema, and the difference were statistical significant (x2=4.114, x2=5.000,x2=4.211;P<0.05); the observation group was higher than control group for treatment satisfaction, and the difference was statistical significant (x2=5.165,P<0.05).Conclusion: The intracranial pressure of brain tumor patients will significantly rise after gamma knife treatment, and the pertinency nursing can reduce the occurrence rates of adverse reaction, intracranial pressure and symptom of encephaledema.
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Objective:To compare the immunology parameters and stress hormone in two groups of patients with lung cancer after radical operation and provide reference to clinical surgery.Methods:From March 2015 to March 2016, 72 cases in our hospital were accepted surgical treatment for lung cancer and divided into observation group and control group. Among them 36 cases of video-assisted thoracoscopy lung cancer radical surgery for the treatment of patients in mind as the observation group, 36 cases of open chest lung cancer radical operation were recorded as control group, respectively comparing two groups of patients with preoperative and postoperative 3 days red cell immune index, index of cellular immunity, stress hormone level and blood rheology index.Results:3 days after operation, the observation group in terms of RBC-C3b, RFER levels were significantly higher than those of control group and RBC-IC and RFER were significantly lower than those in the control group. 3 days after operation, the observation group CD3+, CD4+, CD3+CD4+ were significantly higher than those of the control group, while CD8+ was significantly lower than that of the control group. 3 days after operation, the observation group NE, Cor, angiotensin II (ANG II) was significantly higher than that of the control group (t=2.181,t=10.320,t=5.924;P<0.05). 3 days after operation in observation group, the plasma viscosity, erythrocyte sedimentation equation K value were significantly lower than those in the control group. The differences were statistically significant (t=29.698,t=7.411;P<0.05).Conclusion:The side-effect of thoracoscopy radical resection of lung cancer is small, and it has more advantages compared with open chest lung cancer radical operation.
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Objective: To Study on the application of low temperature plasma sterilizer for endoscopic disinfection and cost, period of validity. Methods: Used duodenum mirrors were collected in December 2012-December 2013 in our department, respectively by low temperature plasma sterilizer with conventional disinfection sterilizer. To compare two methods of sterilization effect and cost, the period of validity. Results: Low temperature plasma sterilizer every time sterilization costs RMB (78.21+7.57), significantly higher than the conventional sterilizer (44.82 5.26) yuan (t=7.71, P<0.05);Low temperature plasma sterilizer sterilization is 5 to 7 months, longer than conventional sterilizer 9-28 d (t=12.50, P<0.05). Conclusion: Low-temperature plasma sterilization method has strong sterilization, temperature, rapid and long shelf life and other advantages, worthy of promotion and application.
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ObjectiveTo explore the effects of ziprasidone and risperidone on cognitive inhibition function through visual pathway of patients with paranoid schizophrenia.MethodsIn the open-label,flexible-dosage trial,124 patients with paranoid schizophrenia were randomly divided into ziprasidone group (120-160 mg/d)and risperidone group(4-8 mg/d) for treatment of 8 weeks.They were assessed with computerized Color Word Test (CWT) and Continuous Performance Test(CPT) through visual pathway for cognitive inhibition function,Positive and Negative Syndrome Scale for efficacy on baseline and 8th weekend.ResultsAfter treatment with ziprasidone,the error number (3.12 ± 5.23 ),the time per correct answer( ( 1.92 ± 1.38 ) s) of CWT,as well as the doubledigit mistaken number (2.31 ± 3.76)and the three-figure mistaken number( 3.15 ±2.80) of CPT reduced more than those before medication ( (4.60 ± 6.80),( 2.74 ± 1.52 ) s,(3.85 ± 3.62 ),(4.42 ± 3.53 ) ) (P ＜ 0.05 ).In risperidone.group,the double-digit mistake number of CPT(3.39 ± 3.59) after pharmacotherapy reduced more than that before pharmacotherapy(4.23 ± 3.88) (P＜ 0.05).After treatment the time per correct answer of CWT and the mistaken numbers of CPT in ziprasidone group were less than those in risperidone group(P＜ 0.05 ),meanwhile,the scores of PANSS in two groups were significantly lower than those before treatment (P ＜ 0.01 ).ConclusionIt is effective for ziprasidone and risperidone to improve the function of cognitive inhibition on patients with paranoid schizophrenia,but there is more dramatic for ziprasidone in short-term treatment.
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Objective To investigate the association between serum cytokines and depression and understand the effect of sertraline on serum leveI of interleukin 2(IL-2),interleukin 6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP).Methods A total of 50 depressive patients(study group) and 25 healthy controls(control group)were included in this study.The levels of serum IL-2,IL-6 and TNF-α were measured by enzymatic-linked immunosorbent assay(ELISA)on baseline and after treatment,CRP were measured by scatter rate nephelometry.Depressive patients were assessed by Hamilton depression sere(HAMD)on baseline and after treatment.Results The levels of IL-2(41.4±15.7)pg/ml,IL-6(63.4±17.2)pg/ml,TNF-α(81.4±19.3)pg/ml and CRP(8.2±2.9)mg/L in study group were significantly higher than those in control group(13.2±4.6)pg/ml,(21.3±7.7)ps/ml,(35.1±7.8)ps/ml,(2.9±0.5)mg/L,(P<0.01).Compared with baseline,the levels of serum IL-2(20.1±9.1)ps/ml,IL-6(38.5±11.6)pg/ml,TNF-a(49.5±12.6)pg/ml and CRP(4.2±1.6)mg/L after treatment by sertraline decreased significantly(P<0.01).In study group,there were significant positive correlations between the serum level of IL-2,IL-6,TNF-α and present age,the total score of HAMD(P<0.05,P<0.01).There were significant positive correlations between variation rates of serum IL-2,IL-6,TNF-αand reduction rate of HAMD(P<0.05,P<0.01).Conclusion The serum levels of IL-2,IL-6,TNF-α and CRP increased in patients with depression.Sertraline may affect depressive patients'serum levels of IL-2,IL-6,TNF-αand CRP.
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OBJECTIVE To investigate the isolation rate and drug-resistance of Stenotrophomonas maltophilia so as to provide evidence for clinical rational use of drugs.METHODS The strains of S.maltophilia isolated from clinical specimens were identified and tested on drug sensitivity by the VITEK-32 system.Parts of the isolates were tested by disc diffusion method.RESULTS A total of 295 strains were identified during from Jan 2005 to Dec 2008.The most of the were isolated from sputum in clinical samples,and ICU was the main distribution department.The result showed that S.maltophilia had higher resistance rate to most drugs.Levofloxacin had the lowest resistance rate followed by trimethoprim-sulfamethoxazole and ciprofloxacin.CONCLUSIONS S.maltophilia has serious resistance rate to common antimicrobial agent showing mult-drug resistance.We should pay more attention to the status,and rationally choose antibiotics according to the drug susceptibility.