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Objective@#This paper analyses the secular trend in physical growth among Japanese children and adolescents from 1900 to 2016, and to provide scientific reference for growth and development in Chinese adolescents.@*Methods@#Data of height and weight of Japanese children and adolescents aged 6-17 years from 1900 to 2016 included in the Survey of School Health Care were used to illustrate growth rate and range of height, weight and BMI during different periods by using one-way ANOVA. Longitudinal correlation between height, weight and BMI was analyzed by using longitudinal analysis method.@*Results@#During 1900 to 2016, height growth ranged between 9.5-19.9 cm in boys and 10.8-18.9 cm in girls aged 6-17 years and the weight growth ranged between 4.0-15.9 kg in boys and 3.9-14.2 kg in girls, with males significantly higher than females; Peak height and weight growth rate of Japanese children and adolescents occurred between 1950 and 1960 (boys: 4.8 cm and 2.7 kg; girls: 3.9 cm and 2.4 kg). On the contrary, from 1939 to 1950, height and weight of Japanese children and adolescents showed a significant decreasing trend (boys: -1.8 cm and -1.2 kg per 10 years; girls: -0.8 cm and -0.4 kg per 10 years); During 2000-2016, the growth rates of height of boys and girls in all age groups in Japan were -0.2 to 0 cm in boys and -0.2 to -0.1 cm in girls per 10 years, respectively.@*Conclusion@#The long-term growth trend of Japanese children and adolescents shows an increasing trend before and after World War II; During World War II and the early post-war period, Japanese children and adolescents showed long-term decreasing trend. In the 21st century, the slow decreasing trend in growth among Japanese children and adolescents is observed, which might associate with absence of favorable environment.
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Objective@#To analyze and compare the correlation between body mass index (BMI) and cardiopulmonary fitness of children and adolescents aged 7 to 18 years in China and Japan, and to provide important reference for healthy development promotion of children and adolescents in China.@*Methods@#A total of 9 594 children and adolescents aged 7-18 years in China and Japan were selected and examined for height, weight and 20 meters shuttle run test (20mSRT), 4 800 of whom were randomly selected and included for analysis. Independent sample t test was used to compare the differences of BMI and 20mSRT between Chinese and Japanese children and adolescents of different sex and age. Logistic regression was used to compare the odds ratio of high cardiopulmonary fitness among children and adolescents of different nutritional status. Pearson correlation and linear regression were used to analyze the correlation between BMI and 20mSRT.@*Results@#Odds ratios of high cardiopulmonary fitness were 0.57, 0.52 and 0.33 in wasting, overweight and obese children and adolescents in China, and 0.49, 0.36 and 0.16 in Japan, respectively, with significant differences(P<0.05). The BMI-Z scores of Chinese and Japanese children and adolescents ranged from - 2.72 to 8.76. There were significant differences in 20mSRT-z between different BMI-Z groups(P<0.05). The 20mSRT-z score of Chinese and Japanese children and adolescents initially increased with BMI-Z score and then decreased with the increase of BMI-z score. With the decrease of BMI-Z score, 20mSRT performance in Chinese boys decreased significantly.@*Conclusion@#Compared with the normal weight peers in China and Japan, the proportion of wasting, overweight and obese children and adolescents with high cardiopulmonary fitness is lower. The BMI-Z score and 20mSRT-z score shows a general inverted "U-shaped" trend. The effect of wasting on cardiopulmonary fitness is greater in Chinese boys.
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Objective@#To determine the relationship between body mass index (BMI) and physical fitness index (PFI) in Chinese and Japanese children and adolescents and to provide theoretical support for physical fitness improvement in Chinese children and adolescents.@*Methods@#A total of 9 594 children and adolescents aged 7-18 years were tested in China and Japan, 4 800 of which with various BMI were randomly selected for analyzing and comparing PFI between the two countries. The relationship between different BMI-Z scores and PFI was analyzed.@*Results@#In general, the PFI of wasting, normal weight, overweight and obesity in Chinese boys was -1.17, -0.03, 0.04 and 0.26, the figures were -2.59, -0.34, -1.46 and -2.44 for Japanese boys, significant differences were found in overweight and obese group (P<0.01). the PFI of wasting, normal weight, overweight and obesity in Chinese girls was -1.18, -0.08, 0.01 and 1.03, the figures were -1.21, 0.51, 0.11 and -1.30 for Japanese girls, significant differences were found in normal weight and obese group(P<0.05). Significant differences in PFI were found within Chinese boys, Chinese children, Japanese boys, Japanese girls and Japanese children with different BMI-Z levels(F=2.89, 3.05, 4.81, 2.33,5.34,P<0.01).@*Conclusion@#There is an inverted "U" curve relationship between BMI and PFI in Chinese and Japanese children and adolescents. With the increase of BMI-Z score, decreasing rate of PFI in Chinese boys is higher than Japanese boys. Practical and effective intervention measures should be taken to improve physical fitness of children and adolescents in China.
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Objective@#To compare physique development of Chinese and Japanese children and adolescents aged from 7 to 18 years and to provide a scientific basis growth and development improvement among Chinese children and adolescents.@*Methods@#In 2016, height and weight of 9 594 children and adolescents aged 7-18 years from China and Japan were collected. A total of 4 800 subjects were randomly selected. Independent sample t test was used to examine differences in height and weight between children and adolescents in the two countries. The LMS method was used to construct percentile curves of the Chinese, Japanese and WHO reference standards.@*Results@#The average height of Chinese children and adolescents was 156.7 cm for boys and 151.3 cm for girls, and that of Japan was 150.8 cm and 146.3 cm respectively. Average height of all ages in China was higher than that of Japan (P<0.05); The average body weight of China was 49.5 kg for boys and 43.8 kg for girls, and for Japan was 43.4 kg and 40.8 kg respectively. Weight in most of the age groups was higher than that of Japan (P<0.05). The detection rates of overweight and obesity and wasting in Chinese boys were higher than those in Japan, while was close to or lower than that of Japan for girls, especially among those who older than 14 years; the third and 50 th percentile (P3 and P50) of height of Chinese children and adolescents was higher than those of Japan; The P50 of body mass index (BMI) in Chinese boys was higher than that of Japan, while the P3 of BMI was lower than that of Japan and WHO standards, and the P3 and P50 of BMI in Chinese girls gradually decreased after 14 years of age, which was lower than that of Japan and WHO standards.@*Conclusion@#For height and weight, Chinese children and adolescents are higher than that of Japan, who also have higher risk of being overweight and obesity than that of Japan. For adolescents over 14 years old, overweight and obesity among Chinese girls is lower than that in Japan, but the proportion of wasting is higher than that of Japan.
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Objective@#To analyze changes in physique change among children and adolescents in Japan from 1900 to 2015, and to provide the scientific basis for national constitution development strategy in China.@*Methods@#Data on height and weight of Japanese children and adolescents aged 6-17 years provided by the Ministry of Foreign Affairs. Cluster analysis was performed to analyze the data.@*Results@#The 5 time periods of highest physique growth rate of Japanese boy and girls were 1948-1950, 1950-1955, 1955-1960, 1960-1965, 1965-1970, and the 5 time periods of lowest growth rate were 1939-1948, 2005-2010, 2000-2005, 1900-1905, 2010-2015, 1995-2000. Physique growth of Japanese children and adolescents showed a relatively constant increasing trend before World War II and the late 20th century, and a rapid increasing trend during 20 years after World War II and a decreasing trend during and short period after World War II. In the cluster analysis, the lower half of male students fell into a single time period (1939-1948) showing the highest rate of decline.@*Conclusion@#Physical changes of Japanese children and adolescents are closely related to the socio-economic environment, and rapid increasing trend is observed during 20 years after World War II. Based on experiences from Japan, rapid socio-economic growth in China provides an important opportunity to promote physical development of children and adolescents. Cautions should be paid to the risk of overweight and obesity accompanied by economic growth.
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In the present study, the effects of bulb type palatal lift prosthesis (bulb-PLP) therapy on nasality and velopharyngeal function (VPF) of patients with velopharyngeal incompetence (VPI) following palatoplasty were longitudinally assessed.The subjects included 18 patients (3 to 52 years of age) who had shown persistent VPI following palatoplasty and who had received bulb-PLP therapy. Nasality and VPF were assessed by perceptual voice analysis, nasometer test, blowing test, and cephalometric radiographic examination. Based on the outcomes of bulb-PLP therapy, the subjects were classified into two groups: the effective group and the ineffective group. Furthermore, the obturating and VPF-activating effects by bulb-PLP therapy were analyzed, and factors relating to different VPF activities were determined.All subjects achieved adequate VPF by wearing a bulb-PLP. After treatment, 10 patients (55.6%) achieved successful activation of VPF without bulb-PLP (the effective group), while persistent VPI remained in 8 patients (the ineffective group). The beginning-blowing ratio of the effective group was significantly greater than that of the ineffective group (P < 0.05) and the velopharyngeal distance (V-P distance) of the effective group tended to be smaller (P = 0.07). Regarding the shape of the bulb head, the angular type was dominant in the ineffective group, while the round type was dominant in the effective group.Bulb-PLP therapy was useful for providing adequate VPF activation. Possible signs of the subsequent effective activation of VPF are considered to be: 1) preexisting adequate VPF on blowing, 2) smaller V-P distance, and 3) synchronized palatopharyngeal movement.
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In order to study the effectiveness of Choreito in the removal of ureteral stones, 7.5g/day of Choreito was administered to 52 patients who had been diagnosed as having ureteral stones. For stones of a diameter less than 4mm, 63.2% were passed within two weeks, and 78.9% within four weeks. The rates for stones between 4 and 10mm was 10% in two weeks and 33.3% in four weeks. For the 52 cases overall, the rate of stone excretion was 28.8% within two weeks and 50% within four weeks.<br>There were no side effects observed in conjunction with Choreito administration.
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A total of 417 operated cases of colorectal cancer at Hiraka General Hospital during the 15-year period from 1974 to 1988 were analyzed and the following results were obtained.<BR>1. There was a distinct tendency to increase in the numbers of resectable cases. By region, cases of cancers in sigmoid colon and upper third of rectum (S+Rs) and right side colon (C+A) were on the rise.<BR>2. The ratio of patients aged over 70 years increased to reach 36 % recently. But the ratio of early stage cancer cases was 7.1 % on the average.<BR>3. The over all resection rate was 90.6 %, and curative resection was performed in 78.5 % of colon cancer cases and 82.0 % of rectal cancer cases respectively.<BR>4. The cumulative 10-year survival rate in curative resected cases was 74.7 % for colon cancer and 70.8 % for rectal cancer.<BR>5. The rate of multiple cancer cases was as high as 13.4 %.
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A total of 1, 236 cases of gastric cancer operated at Hiraka general hospital during the 14 years from 1975 to 1988, were analyzed and the following results were obtained.<BR>1. There was a distinct tendency to increase in the numbers of early-staged cancer cases and patients over 70 years of age.<BR>Any decrease in the number of operated gastric cancers could not be obeseverd during this period.<BR>2. The ratio of patients aged over 70 years increased to reach 26.4% recently and the ratio of early staged cancer increased to 59.3% in 1988.<BR>3. The over all resection rate was 90.8% and curative resection was performed in 85.2% of resected cases.<BR>4. The cumulative 10-year survival rate in curative resected cases was 74.0%.<BR>5. The rate of the multiple cancer cases was as high as 5.0%.
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The present studies on gallstones, made by macroscopic morphology and infrared absorption spectra, were carried out in order to clarify recent features of cholelithiasis in rural district. One hundred and sixty-one stones obtained from 152 patients who had cholelithiasis, and who were operated-on at our clinics during the past 10 years, were used for this study.<BR>The average age of the patients was 62 years, and about half of them were over 65 years of age. The patients included 100 women and 52 men. The types and frequency of gallstones are classified as follows: cholesterol stones, 50.9%; pigment stones, 40.4%(black stones, 7.5%; bilirubin stones, 32. 9%) and rare stones, 8.7%. Considerin sexual differences, the frequency of cholesterol stones was nearly 2 times greater in women than in men; on the other hand, that of pigment stones was nearly 2 times higher in men than in women. Regarding the age groups of the patients, although the incidence of cholesterol stones was greater in the group under 64 years of age than in the 65-year-old group, the incidence of bilirubin stones was 4 or more times higher in the latter group than in the former.<BR>From the above observations it is suspected that one of the major reasons for the low incidence of cholesterol stones in rural districts, is because of the high percentage of elderly patients with cholelithasis in these areas. The incidence of black stones was not significantly greater in rural districts.
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This present study was conducted among the nine centers of Akita prefectural Welfare Federation of Agricultural Cooperatives. This applied to women over 30 years of age, and carried out following to the standard method of the Japan Cancer Society.<BR>The total of women examined by the first screening from April 1983 to January 1985 amounted to 15903, of which the number of women over 60 years of age was only 7 per cent of the total. According to the type of screening, the number of women slightly more in the center screening than in the local screening. However, in both types of screening, the number of women examined by the combination method, for example, anemia or uteric cancer, was much higher than that of the mass screening for breast cancer alone.<BR>The second screening rates indicaded a marked difference of 0.4 to 21.7 per cent depending on the location of the center. The over-all average for the second screening was 3.8 per cent. As a result of the second screening, breast cancers were detected in 12 cases (0.07%). The breast cancer detection rate increased with age. It is notable that the breast cancer detection rate for women over 60 years of age was 5 times higher than for women over 40 years of age. Among other diseases detected in the second screening were mastpathy (233 cases), fibroadenoma (15 cases), mastitis (40 cases) and others.<BR>As far the stage distribution and screening history for detected breast cancers, 60 per cent of all cancer cases were diagnosed as stage I, and 70 per cent were the initial screening. Seven out of 12 cases were aware the breast lump themselves before the first screening. From this point of view, it was suggested that every women should be educated in order to perform selfexamination.
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We investigated the content of NO<SUB>3</SUB>-N in the well water of the eastern, middle and nothern districts of Nagano Prefecture. The NO<SUB>3</SUB>-N content seasonally changes and takes on the pattern of a high in summer and a low in winter.<BR>Rain is considered to dilute the contaminated well water, but it lets NO<SUB>3</SUB>-N flow from the soil into the.well water, when the rain is poured by a typhoon. As a result, a high content of NO<SUB>3</SUB>-N is measured in the well water.<BR>The water sample of 25 out of 85 wells in Matsukawa Town exceeded the tolerance level of NO<SUB>3</SUB>-N (10 ppm, but 44.3 ppm in terms of NO<SUB>3</SUB><SUP>-</SUP>).<BR>By crop area, the amount of NO<SUB>3</SUB>-N was highest in the fruitgrowing area, which was followed in order of the vegetable-growing area, the flower-growing and the rice planting area.<BR>We consider that the contamination of well water is caused both by chemical fertilizers and the less absorbility of the soil.
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To demonstrate delayed neuro-toxicity of organophosphate, we administered 13 types of organophosphorous pesticide to hens. Initially, a screening test was performed with nine varieties of the chemical product. Later, four types were given to the fowls. Those hens dosed with S-Seven and Surecide developed ataxia and other neurophatic symptoms in the lower limbs.<BR>After 50 days of observation, all the hens were killed and anatomized. Phathohistological examination revealed various changes in the hens that developed neuropathic symptoms: atrophy, diminution and disappearance of nerve cells in the anterior horn of the spinal cord ; edematous changes in the myelin; swelling of the neuroglia ; atrophy and vaculolar degeneration of liver cells; and necrobiosis of <I>nepaticlobures</I>.<BR>It was found that these changes are closely related with the development of ataxia and doses of the chemical.<BR>It was also found that the pathotistological changes occurred to a less extent in those hens which did not develop toxicoses.
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Over the past eight years, small doses of an organophosphorous insecticide known in Japan as Sumithion (fenitrothion) have been administered weekly to rehsus monkeys and beagles. In this report, the results obtained during the past three years are discussed.<BR>During the period, two monkeys and one hound died. Pathohistological examination revealed degeneration and disappearance-regeneration of liver tissues, edema of oculomotor muscle stomas, spinal cords and oculomotorius nerve fibers, and atrophy of limph nodes. These are considered the effects of the insecticide.<BR>The surviving animals did not develop any abnormal changes or signs associated with Sumithion-induced disorders. Weight loss was not observed. Routine blood tests were negative. However, serum chemical analyses conducted in the seventh year showed that there are statistically significant differences in GPT, LDH and cholinestrase activity among the animals.
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Two hundred and thirty adipose tissues were collected from inpatients, who had undergone an operation and an autopsy in the Saku Central Hospital from 1980 to 1982. Organochlorine pesticides were extracted from the adipose tissues and determined by gas-liquid chromatography with an electron-capture detector.<BR>The mean value was 1, 429 ppm for total BHC among males, and 1.665 ppm among females, 4.893 ppm and 3.791 ppm for total DDT, 1.082 ppm and 0.782 ppm for PCB, respectively. Regression analysis between the total BHC residue and the ages of patients indicated a positive correlation for both sexs. As for the relation between the rate of obesity and the residues, low rates of obesity (-10%--19%) were most significantly correlated with high values of total BHC, total DDT and PCB.<BR>We also discussed relations between cancerous diseases and the residues.