ABSTRACT
The ethanol extract of Polygala rosmarinifolia whole plant (Family: Polygalaceae) was investigated for its antihyperglycemic and antihyperlipidaemic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of alloxan monohydrate (150mg/kg, i.p). The ethanol extracts of Polygala rosmarinifolia at a dose of 100 and 200mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of Polygala rosmarinifolia whole plant extract on blood glucose, serum insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglycerides (TG), low density lipoprotein – cholesterol (LDL-C), very low density lipoprotein–cholester (VLDL-C), high density lipoprotein – cholesterol (HDL-C) and phospholipid (PL)] serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminases (SGPT), serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)], were measured in the diabetic rats. The ethanol extract of Polygala rosmarinifolia whole plant elicited significant reductions of blood glucose (P<0.05), lipid parameters except HDL-C, serum enzymes and significantly increased HDL-C. The extracts also caused significant increase in serum insulin (P<0.05) in the diabetic rats. From the above results, it is concluded that ethanol extract of Polygala rosmarinifolia possesses significant antihyperglycemic and antihyperlipidaemic effects in alloxan induced diabetic rats.
ABSTRACT
The present study aims to evaluate the antitumor activity of ethanol extract of whole plant of Polygala rosmarinifolia on DAL model in Swiss Albino mice. Evaluation of the antitumor effect of ethanol extract of whole plant of Polygala rosmarinifolia on tumor growth and host survival time was made by the study of the following parameters: tumor volume, viable and non viable cell count and life span of host. The results showed decrease in tumor volume and cell viability. Hematological studies revealed that, the Hb count decreased in DAL treated mice, whereas it was induced by the drug treated animals and showed an increase in Hb near to normal levels. The results suggested that the extracts of whole plant of Polygala rosmarinifolia exhibited significant antitumor activity on DAL bearing mice.
ABSTRACT
This study was carried out to analyze the active constituents present in the whole plant of Polygala rosmarinifolia. Twelve compounds in ethanol extract were identified by Gas chromatography-Mass spectrometry (GC-MS) analysis. 1, 5–Anhydro-d-mannitol (73.35%) was the prevailing compound in ethanol extract, which is suggested to be an anticancer compound. This is the first report of identification of active constituents from whole plant of Polygala rosmarinifolia.