effect of propofol administration on the intraocular pressure

The use of propofol [2, 6, -diisoproylphenol] as an induction agent for general anaesthesia, has been reported to be smooth, without major adverse effects and associated with smooth recovery[1]. Previous studies have shown that its use is also associated with significant reduction in intraocular pressure [IOP][2]. In addition its use is beneficial in attenuating the rise in IOP assocaited with tracheal intubation. This study was undertaken to define the effects of propofol on IOP of normal and glucomatus eye when given as a single bolus dose of 2 mg Kg[1] intravenously followed by atracurium of intubation

Comparison of the effects of nalbuphine, fentanyl and pethidine in rabbits pretreated wilth a monoamine oxidase inhibitor tranylcypromine [parnate]

The existence of a severe toxic interaction from the clinical use of pethidine and monoamine oxidase [MAO] inhibitors is well known. The present study evaluates the possibility of such an interaction for the opioid partial agonist Nalbuphine and the pure agonist fentanyl. Conscious rabbits [n = 6] in each group pretreated 24 hours previously with physiological saline or the MAO inhibitor tranylcypromine [Parnate] 1.5 mg/kg S.C. were subsequently given physiological saline, pethidine 5 mg/kg, fentanyl 0.02 mg/kg and effect and parnate produced only a small increase in the rabbits temperature, the combination of parnate and pethidine produced a marked hyperpyrexia [+ 4.4 +/- 0.19°C, P < 0.001], hypertension 33.9 +/- 3.1 mmHg; P < 0.01] and agitation. Two rabbits died at 40 and 50 minutes after the pethidine- parnate combination. Nalbuphine and fentanyl were without significant effects on the parameters when given after the MAO-inhibitor parnate