ABSTRACT
Abstract: Angiosarcoma is a rare and aggressive tumor with high rates of metastasis and relapse. It shows a particular predilection for the skin and superficial soft tissues. We report three distinct and typical cases of angiosarcoma that were diagnosed in a single dermatology clinic over the course of less than a year: i) Angiosarcoma in lower limb affected by chronic lymphedema, featuring Stewart-Treves syndrome; ii) a case of the most common type of angiosarcoma loated in the scalp and face of elderly man and; iii) a skin Angiosarcoma in previously irradiated breast. All lesions presented characteristic histopathological findings: irregular vascular proliferation that dissects the collagen bundles with atypical endothelial nuclei projection toward the lumen.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged, 80 and over , Scalp/pathology , Skin Neoplasms/pathology , Head and Neck Neoplasms/pathology , Hemangiosarcoma/pathology , Breast/pathology , Risk Factors , Leg/pathology , Lymphangiosarcoma , Lymphedema/complicationsABSTRACT
Abstract Diffuse cutaneous melanosis is a rare complication of metastatic melanoma related to a worse prognosis. There are few cases reported in the literature. Its pathogenesis has not been completely elucidated, although studies have suggested certain mechanisms for its occurrence. It is clinically manifested as a blue-gray discoloration of the skin and mucous membranes in a cephalo caudal progression and usually associated with melanuria. Skin and mucosa histopathology reveals only the presence of melanophages in the dermis, mainly perivascular, and free interstitial melanin. We report the case of a 68-year-old male with metastatic melanoma, diffuse hyperpigmentation of the skin and melanuria.
Subject(s)
Humans , Male , Middle Aged , Skin Neoplasms/complications , Melanoma/complications , Melanosis/etiology , Skin/pathology , Skin Neoplasms/pathology , Skin Neoplasms/secondary , Biopsy , Fatal Outcome , Liver Neoplasms/pathology , Lung Neoplasms/pathology , Melanins/urine , Melanoma/pathology , Melanoma/secondary , Melanosis/urine , Melanosis/pathologyABSTRACT
Abstract Lucio’s phenomenon is an uncommon reaction characterized by severe necrotizing cutaneous lesions that occurs in patients with Lucio’s leprosy and lepromatous leprosy. It is considered by some authors as a variant of type 2 or 3 reaction. Death can occur because of blood dyscrasia or sepsis. Precipitating factors include infections, drugs and pregnancy. We report a 31-year-old female patient exhibiting both clinical and histopathological features of lepromatous leprosy and Lucio’s phenomenon presenting favorable response to treatment. We complement our report with a literature review of the Brazilian cases of Lucio’s phenomenon published in Portuguese and English.