relationship between some endometrial secretion cytokines and in vitro fertilization

Endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity. The aim of the present study was to assess the relationship between the success rate of IVF procedures and some endometrial secretion cytokines, including interleukin-1beta [IL-1beta], tumor necrosis factor [TNF-alpha], interferon gamma-induced protein 10 [IP-10], and monocyte chemoattractant protein [MCP]. In a prospective cohort study, 50 women selected for IVF met the study inclusion criteria. All the patients underwent endometrial secretion aspiration prior to embryo transfer. The level of IL-1beta, TNF-alpha, IP-10 and MCP were analyzed by enzyme-linked immunosorbent assay method using special standard kits. To detect successful implantation and pregnancy patients underwent serum human chorionic gonadotropin measurements and ultrasound evaluation. Five samples were excluded. Nine women [20%] had successful clinical pregnancies, which resulted in live birth. Other 36 women [80%] were classified as failed pregnancy. Comparison of cytokine levels showed lower concentrations of TNF-alpha, IP-10, and MCP in the group with successful clinical pregnancy compared to the group with failed pregnancy [p=0.007, 0.005 and 0.001, respectively]. However, no significant difference was revealed in IL-1beta levels between two groups [p=0.614]. The current study suggested that lower concentrations of TNF-alpha, IP- 10, and MCP in endometrial secretions might be associated with improved endometrial receptivity and IVF outcome. Regarding IL-1beta, no statistically significant differences were seen between the groups with and without successful pregnancy

relationship between clinicobiochemical markers and depression in women with polycystic ovary syndrome

Previous studies have demonstrated that clinical features of 16TPolycystic ovary syndrome16T [PCOS] are associated with a lower degree of health, self, and sex satisfaction. Our study aimed to investigate possible associations between depression and different clinicobiochemical markers of PCOS. In a cross-sectional analytic study, 120 PCOS women aged 18-45 yr, were enrolled. Beck Depression Inventory was used to assess depression. Also, all participants underwent biochemical studies. Individuals with 15 points and more in Beck test were referred to a psychiatrist to participate in a complementary interview for the diagnosis of depression based on Diagnostic and Statistical Manual of Mental Disorders IV [DSMIV-TR] criteria. Among the study participants, 82 women [68.3%] were non-depressed, and 38 patients [31.7%] had some degrees of depression. According to the psychiatric interview, 10 patients [8.3%] had major depression, 22 patients [18.3%] had minor depression and 6 patients [5%] had dysthymia. We failed to show any significant difference in body mass index, hirsutism, infertility, serum total testosterone, lipid profile, and the homeostasis model assessment of insulin resistance [HOMA-IR] between depressed and non-depressed subjects [p>0.05]. Using Spearman correlation, we did not find a positive correlation between BDI scores and clinicobiochemical markers for all PCOS subjects [-0.139 0.05]. In spite of high rate of depression in women with PCOS, there was no significant association between Clinicobiochemical Markers and depression