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Induction and nosocomial dissemination of carbapenem and polymyxin-resistant Klebsiella pneumoniae

Gaspar, Gilberto Gambero; Bellissimo-Rodrigues, Fernando; Andrade, Leonardo Neves de; Darini, Ana Lúcia; Martinez, Roberto.

Rev. Soc. Bras. Med. Trop ; 48(4): 483-487, July-Aug. 2015. tab, ilus

Article in English | LILACS | ID: lil-755967

ABSTRACT

INTRODUCTION:

Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection.

METHODS:

We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae.

RESULTS:

Three patients were hospitalized in adjacent wards, and two were admitted to the intensive care unit. The index case maintained prolonged intestinal colonization by KPC-producing K. pneumoniae. Three patients received polymyxin B before the isolation of polymyxin-resistant K. pneumoniae.

CONCLUSIONS:

Colonization by KPC-producing K. pneumoniae and previous use of polymyxin B may be causally related to the development of polymyxin-resistant microorganisms.

Subject(s)

Adult , Aged , Female , Humans , Male , Middle Aged , Anti-Bacterial Agents/pharmacology , Cross Infection/microbiology , Klebsiella Infections/microbiology , Klebsiella pneumoniae/drug effects , Polymyxins/pharmacology , Carbapenems/pharmacology , Drug Resistance, Bacterial , Klebsiella pneumoniae/isolation & purification , Microbial Sensitivity Tests

ABSTRACT

Subject(s)

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