ABSTRACT
Peroxidase was extracted from Brassica oleracea var alboglabra. The potential of crude Brassica oleracea var alboglabra peroxidase as a biocatalyst for the dimerization of guaiacol is presented. The products of the reaction were isolated and have been fully characterized by spectroscopic methods. One new coupling dimer of O-para dehydroguaiacol was obtained. Bioactive of this compound exhibited have strong antioxidant activity on DPPH radicals, with IC50 value of 4.69 μM.
ABSTRACT
Cinnamic acid derivative compound was investigated for the anti-cancer inhibitory activity. To be able to obtain compounds that have bioactivity as above, it is needed to study quantitative structure-activity relationship (QSAR) which is the process by which the chemical structure is quantitatively correlated with biological activity/chemical reactivity. Chemical methods used in synthesizing the chemical of methyl trans-cinnamate derivatives are tailored to match their targeted bioactivities. Here, we investigated the anti-cancer inhibitor compound with the method amidation of cinnamic acid derivative compounds. In this reaction we use two steps to get the target product. Firstly, we hydrolize of methyl trans-cinnamate to cinnamic acid. That reaction has a yield 85.5 % and secondly, we amidate of cinnamic acid to metil 2-cinnamamido-3-hydroxy propanoate has a yield of 51.5%. The compound of metil 2-cinnamamido-3-hydroxy propanoate showed against P388 leukemia cells inhibitory activity with IC50 = 10.78 μg/mL.
ABSTRACT
HDL-cholesterol raising effect of atorvastatin was compared to that of dehydrolovastatin in an 8-week study in 5 equally-membered groups of pre-acclimatized Sprague-Dawley rats. The first and second groups were normal and hyperlipidemic control, while the others were treated with atorvastatin 14.4 mg, dehydrolovastatin 7.2 mg, and dehydrolovastatin 14.4 mg, per 200 g of mouse body weight per day, respectively. Slightly better effect than atorvastatin\ s could only be achieved by dehydrolovastatin with the same dose.