ABSTRACT
Resumen Objetivo: Analizar las evidencias científicas sobre los cambios ocurridos en los estilos de vida saludables asociados al confinamiento por COVID-19 en población adulta de 19 a 59 años. Materiales y métodos: Se realizó una revisión sistemática siguiendo los criterios de la guía PRISMA durante el período de búsqueda de marzo de 2020 a febrero de 2022 en las bases de datos PubMed, Google académico y Cochrane usando las palabras clave "COVID-19, lifestyles, obesity, confinement, quarantine" previamente validadas en MeSH del NCBI y DeCs. Resultados: La búsqueda en las bases de datos de PUBMED, google académico y Cochrane arrojó un total de 702 artículos, tras eliminar los artículos duplicados, se recuperaron 94 artículos, después del primer y segundo cribado se excluyeron 45 artículos, trabajando finalmente con 49 artículos. La evidencia muestra que el confinamiento modificó negativamente los estilos de vida saludables favoreciendo conductas como sedentarismo, asociado a mayor tiempo en el uso de dispositivos electrónicos. Además, incrementó el consumo de alimentos hipercalóricos, la ingesta de alimentos poco saludables entre comidas, raciones más grandes e incrementó en el número de comidas al día, aunado a la disminución en la actividad física, el incremento del consumo de alcohol y cigarros factores que influyeron en el desarrollo de sobrepeso y obesidad. Conclusiones: Las evidencias muestran cambios negativos en los estilos de vida saludables que se asociaron con sobrepeso y obesidad durante el confinamiento por COVID-19, ante este panorama se requieren de estrategias de intervención integrales basados en programas de nutrición saludable y activación física con la finalidad de disminuir o revertir los efectos causados por el confinamiento.
Abstract Objective: To analyze the scientific evidence on the changes that have occurred in healthy lifestyles associated with confinement by COVID-19 in the adult population between 19 and 59 years of age. Materials and methods: A systematic review was carried out following the criteria of the PRISMA guide during the search period from March 2020 to February 2022 in the PubMed, Google Scholar, and Cochrane databases using the keywords COVID-19, healthy lifestyles, obesity, overweight, confinement, quarantine, lockdown, previously validated in NCBI MeSH and DeCs. Results: The search in the PUBMED, Google Scholar, and Cochrane databases yielded a total of 702 articles. After eliminating duplicate articles, 94 articles were recovered. After the first and second screening, 45 articles were excluded, finally working with 49 articles. Evidence shows that confinement negatively modified healthy lifestyles, favoring behaviors such as a sedentary lifestyle, associated with longer use of electronic devices. In addition, there was an increase in the consumption of hypercaloric foods, the intake of unhealthy foods between meals, larger portions, and an increase in the number of meals per day, together with a decrease in physical activity, an increase in the consumption of alcohol and cigarettes, factors that influenced the development of overweight and obesity. Conclusions: The evidence shows negative changes in healthy lifestyles that were associated with overweight and obesity during the confinement by COVID-19, in view of this panorama, comprehensive intervention strategies are required based on healthy nutrition programs and physical activation with the purpose of to reduce or reverse the effects caused by confinement.
ABSTRACT
Candida glabrata is an opportunistic fungal pathogen that can cause severe invasive infections and can evade phagocytic cell clearance. We are interested in understanding the virulence of this fungal pathogen, in particular its oxidative stress response. Here we investigated C. glabrata, Saccharomyces cerevisiae and Candida albicans responses to two different oxidants: menadione and cumene hydroperoxide (CHP). In log-phase, in the presence of menadione, C. glabrata requires Cta1p (catalase), while in a stationary phase (SP), Cta1p is dispensable. In addition, C. glabrata is less resistant to menadione than C. albicans in SP. The S. cerevisiae laboratory reference strain is less resistant to menadione than C. glabrata and C. albicans; however S. cerevisiaeclinical isolates (CIs) are more resistant than the lab reference strain. Furthermore, S. cerevisiae CIs showed an increased catalase activity. Interestingly, in SP C. glabrata and S. cerevisiae are more resistant to CHP than C. albicans and Cta1p plays no apparent role in detoxifying this oxidant.