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Clinical and Experimental Reproductive Medicine ; : 107-111, 2019.
Article in English | WPRIM | ID: wpr-763364

ABSTRACT

OBJECTIVE: Spermatogenesis is a complex process that is regulated by a number of genes, some of which are involved in folate-dependent 1-carbon metabolism. Methionine synthase (encoded by MTR) is a key enzyme participating in this pathway. This study aimed to investigate the relationship of the MTR 2756A > G polymorphism with idiopathic male fertility in the Iranian population. METHODS: The participants of this study included 100 men with idiopathic infertility and 100 healthy men as the control group. Genotyping of MTR 2756A > G was performed using the polymerase chain reaction and restriction fragment length polymorphism technique. The obtained data were analyzed using SPSS ver. 20.0 with a level of confidence of p G single-nucleotide polymorphism is not a predisposing factor for idiopathic infertility in men.


Subject(s)
Humans , Male , Male , 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase , Alleles , Causality , Fertility , Genotype , Infertility , Infertility, Male , Metabolism , Methionine , Models, Genetic , Polymerase Chain Reaction , Polymorphism, Restriction Fragment Length , Spermatogenesis
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