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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus (CoV), has recently emerged as a significant pathogen for humans and the cause for the recent outbreak of the 2019 novel coronavirus disease (COVID-19) throughout the globe. For developing any preventive measure, an understanding of the zoonotic pattern for this virus is a necessity. We should have a clear knowledge of its reservoir host, its distribution pattern and spreading routes. Information about zoonotic reservoirs and its transmission among them can help to understand the COVID-19 outbreaks. In this article, we discuss about the bats as the zoonotic reservoir of several CoV strains, co-existence of bats and CoV/viruses, the sequence similarity of SARS-CoV-2 with bat SARS-like CoV, the probable source of the origin of SARS-CoV-2 strain and COVID-19 outbreak, intermediate host of CoVs and SARS-CoV-2, human to human transmission and the possibility to maintain the zoonotic barriers. Our knowledge about the zoonotic reservoir of SARS-CoV-2 and its transmission ability may help develop the preventive measures and control for the future outbreak of CoV.
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OBJECTIVES: To appraise the effectiveness of platelet-rich fibrin (PRF) in the management of established dry socket in terms of pain, inflammation, and wound healing. MATERIALS AND METHODS: Two hundred patients with established alveolar osteitis were studied to determine the efficacy of PRF and zinc oxide eugenol (ZOE) for pain control, inflammation reduction, and wound healing. Patients were randomly allocated to Group A (PRF) or Group B (ZOE). Patients were examined on the 1st, 3rd, 7th, and 14th postoperative day and evaluated for pain using visual analogue scale scores, inflammation with a gingival index score, and wound healing through a determination of the number of bony walls exposed. RESULTS: Group A showed better results in terms of pain remission, control of inflammation, and wound healing compared to Group B. Results between groups were statistically significant (P<0.05). CONCLUSION: PRF is a better alternative than ZOE for the effective management of alveolar osteitis.
Subject(s)
Humans , Dry Socket , Eugenol , Fibrin , Inflammation , Periodontal Index , Wound Healing , Wounds and Injuries , Zinc Oxide , ZincABSTRACT
This article has been retracted at the request of the Editorial Board.The Editorial Board consulted with the KAMJE (Korean Association of Medical Journal Editors) about ‘Imalas’ matter of the publication and concluded as following:The Paper A is an article on the study of pain, inflammation and formation of granulation tissue using platelet rich fibrin (PRF) for dry socket treatment after tooth extraction. This study was conducted on 100 patients at Teerthankar Mahaveer Dental College and Research Center, Moradabad, from September 2014 to March 2016. The Paper B is a research based on the same conditions as Paper A. This study was conducted on 100 patients using PRF and 100 patients using zinc oxide eugenol, from August 2014 to December 2017. The study was held at the Kothiwal Dental College and Research Centre (KDCRC), Moradabad. The clinical factors studied in above two articles are the same, and the pain scale in Fig. 3 in Paper A is almost identical to the Fig. 2, Group A in Paper B; and Fig. 5 in Paper A is also same as Fig. 4, Group A in Paper B. Both papers are judged to have the overlapping publication in the similar period and the patient, and it is considered intentional not to cite Paper A in Paper B. Therefore, Paper B is believed to be a significant double publication. For this reason, the Editorial Board decided to retracted this article and sincerely apologize for any inconvenience this may have caused.
ABSTRACT
This article has been retracted at the request of the Editorial Board.The Editorial Board consulted with the KAMJE (Korean Association of Medical Journal Editors) about ‘Imalas’ matter of the publication and concluded as following:The Paper A is an article on the study of pain, inflammation and formation of granulation tissue using platelet rich fibrin (PRF) for dry socket treatment after tooth extraction. This study was conducted on 100 patients at Teerthankar Mahaveer Dental College and Research Center, Moradabad, from September 2014 to March 2016. The Paper B is a research based on the same conditions as Paper A. This study was conducted on 100 patients using PRF and 100 patients using zinc oxide eugenol, from August 2014 to December 2017. The study was held at the Kothiwal Dental College and Research Centre (KDCRC), Moradabad. The clinical factors studied in above two articles are the same, and the pain scale in Fig. 3 in Paper A is almost identical to the Fig. 2, Group A in Paper B; and Fig. 5 in Paper A is also same as Fig. 4, Group A in Paper B. Both papers are judged to have the overlapping publication in the similar period and the patient, and it is considered intentional not to cite Paper A in Paper B. Therefore, Paper B is believed to be a significant double publication. For this reason, the Editorial Board decided to retracted this article and sincerely apologize for any inconvenience this may have caused.
ABSTRACT
OBJECTIVES@#To appraise the effectiveness of platelet-rich fibrin (PRF) in the management of established dry socket in terms of pain, inflammation, and wound healing.@*MATERIALS AND METHODS@#Two hundred patients with established alveolar osteitis were studied to determine the efficacy of PRF and zinc oxide eugenol (ZOE) for pain control, inflammation reduction, and wound healing. Patients were randomly allocated to Group A (PRF) or Group B (ZOE). Patients were examined on the 1st, 3rd, 7th, and 14th postoperative day and evaluated for pain using visual analogue scale scores, inflammation with a gingival index score, and wound healing through a determination of the number of bony walls exposed.@*RESULTS@#Group A showed better results in terms of pain remission, control of inflammation, and wound healing compared to Group B. Results between groups were statistically significant (P<0.05).@*CONCLUSION@#PRF is a better alternative than ZOE for the effective management of alveolar osteitis.
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Objective: Druggability of a target protein depends on the interacting micro-environment between the target protein and drugs. Therefore, a precise knowledge of the interacting micro-environment between the target protein and drugs is requisite for drug discovery process. To understand such micro-environment, we performed in silico interaction analysis between a human target protein, Dipeptidyl Peptidase-IV [DPP-4], and three anti-diabetic drugs [saxagliptin, linagliptin and vildagliptin]
Materials and Methods: During the theoretical and bioinformatics analysis of micro-environmental properties, we performed drug-likeness study, protein active site predictions, docking analysis and residual interactions with the protein-drug interface. Micro-environmental landscape properties were evaluated through various parameters such as binding energy, intermolecular energy, electrostatic energy, van der Waals'+H-bond+desolvo energy [EVHD] and ligand efficiency [LE] using different in silico methods. For this study, we have used several servers and software, such as Molsoft prediction server, CASTp server, AutoDock software and LIGPLOT server
Results: Through micro-environmental study, highest log P value was observed for linagliptin [1.07]. Lowest binding energy was also observed for linagliptin with DPP-4 in the binding plot. We also identified the number of H-bonds and residues involved in the hydrophobic interactions between the DPP-4 and the anti-diabetic drugs. During interaction, two H-bonds and nine residues, two H-bonds and eleven residues as well as four H-bonds and nine residues were found between the saxagliptin, linagliptin as well as vildagliptin cases and DPP-4, respectively
Conclusion: Our in silico data obtained for drug-target interactions and micro-environmental signature demonstrates linagliptin as the most stable interacting drug among the tested anti-diabetic medicines
Subject(s)
Humans , Molecular Targeted Therapy , Protein Binding , Drug Discovery , Dipeptidyl Peptidase 4/drug effects , Dipeptidyl-Peptidase IV Inhibitors , Models, MolecularABSTRACT
Background: Conjunctivitis is the inflammation of the conjunctiva and has 4 main causes-viruses, bacteria, allergens, and irritants. Among these, bacterial conjunctivitis is most common and is contagious, especially when the dentist is working with the infected person, and that person spreads the same to the other patient
Methods: A pretested questionnaire survey was conducted among 152 subjects [those who were present at the time of survey] aged 18 to 60 years of Udaipur city, Rajasthan in March 2012. Ethical clearance was obtained from relevant authority. Written informed consent was obtained from study participants
Results: All [80 dentists and 72 dental auxiliaries] the subjects returned the questionnaire. Regarding previous experience of eye flu, 67 [44.08%] participants reported that they had been infected with eye flu previously. Majority 123 [80.92%] of participants agreed that virus or bacteria caused eye flu. Majority of 145 [95.39%] of the participants agreed that the eye turns red during eye flu. One hundred and twenty three [80.92%] subjects replied that the dental treatment for a patient infected with eye flu should be delayed till the symptoms subside
Conclusions: Eye flu being an occupational hazard among dentists, personal ophthalmic prophylactic care is a must which helps in prevention of spread of infection to other patients and family members
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The concept of a public-private partnership [PPP] has been proposed as a potential model for providing education services besides public finance and public delivery. The present study was conducted to survey the current practices of Private-Public Partnership [PPP] in health education in Udaipur city, Rajasthan, India. A questionnaire survey was conducted among organizations involved exclusively and actively in health education in Udaipur city, Rajasthan, India. The pretested self designed structured questionnaire consisted of 21 items pertaining to the current practices of private-public partnership [PPP] in health education. Descriptive statistics were used to describe the data. On the basis of inclusion criteria, 50 personnel from 2 private dental colleges, 1 private medical college, 2 Non Government Organizations [NGOs] and 1 health museum were selected. Only 15 [30%] of participants agreed that they have a written reference policy that outlines the services they provide to the general public. Regarding the collection of health education materials available, majority 35 [70%] had printed books followed by audio visual [AV] materials [slides, videos, audio cassettes] [22 [44%]]. 35 [70%] of participants reported that they loan only pamphlets and broachers to the public. Thirty four [68%] of participants provide information about oral health. Only 23 [46%] of participants reported that their institution/organization undergo periodic evaluation. Results of this survey show that that most of the PPP were involved in delivering health education, mostly concentrated on general health. Only few of them were involved in oral health education. The role of PPP in health education is integral to the effort of promoting a healthier population. This effort continues the trend and broadens the scope of involvement for further studies
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AIM: To evaluate anti cataract effect of phyllanthus niruri (PN) both in vitro and in vivo galactose induced cataract.METHODS: Aqueous extract of PN was evaluated against galactose-induced cataract both in vitro and in vivo. Galactosaemic cataract was induced in rats by feeding 300g/L galactose diet. PN was administered orally at three-dose levels 75, 150 and 300 mg/kg of body weight. Rat lenses were subjected to osmotic stress in vitro by incorporating galactose (30mmol/L) in the culture medium. The effect of PN (720 and 880μg/mL) on the glutathione (GSH) and polyols levels was studied.RESULTS: PN significantly delayed the onset and progression of cataract in vivo. In addition to the delay in reaching various stages of development of cataract, stage IV did not develop with lower doses till the completion of experimental period. Lenses treated with PN 880μg/mL concentration showed higher levels of GSH and decreased levels of polyols in vitro. In vivo, 75mg/kg significantly delayed the onset and progression of cataract as compared to control.CONCLUSION: PN delayed the process of cataracto-genesis in the experimental models. However, further study is required to extrapolate the use in human beings for the prevention of cataract.