ABSTRACT
The aim of this study was to find the incidence of human T. Cell leukemia virus [HTLV-I] in acute lymphatic leukemia and lymphomas in Alexandria. 100 cases of acute lymphatic leukemia and lymphoma attended the Main University Hospital, out patient clinics and internal medicine department-150 Control of other types of leukemias, cancer and normal subjects attending also the out patient clinics and internal medicine department. The patients and controls were subjected to the following: Clinical examination, White cell count total and differential, Bone marrow Aspiration, Lactic acid dehydrogenase enzymens, Serum calcium, Erythrocytic Sedmentation Rate [E.S.R.], C-reactive protein [C.R.F.], Anti HTLV-1 antibodies using SERODI-HTLV-1 [passive particle agglutination test manufactured by FUJIREBIO Inc. Tokyo-Japan]. HTLV-I Ab was positive in 14% in cases of acute lymphatic leukemia and lymphoma. While, it was positive in the control group compared to Normal subjects and other types of leukemia and cancer [3.3%]. It was found that HTLV-1 virus in acute lymphatic leukemia is less than in other endemic areas. Trials for immunization are urgent. Blood blanks examination for the virus is essential, where it is transmitted by 1] blood 2] mother to child [breast feeding] 15 and transpiacental, 3] Sexually transmitted disease [STD]
Subject(s)
Humans , Male , Female , Lymphoma , Deltaretrovirus , PrevalenceABSTRACT
Background: Recurrence or persistence of a chronic venous insufficiency ulcer could be multifactorial. Incompetent perforators, presence of associated arterial insufficiency, are possible causes that are easily identified during color duplex limb check A section of those recurrent ulcers did not have an apparent explanation until attention was drawn to a hidden factor which is vasculitis
Aim of the work: To identify vasculities as a cause of persistent or recurrent venous ulcer in the lower extremity, and to observe response to vasculities treatment, upon healing of the venous ulcer
Patients: Seventeen patients with non-healing venous ulcer [CEAP 6] were studied, where neither arterial insujfzciency nor any more leaking perforators were present
Methods: Repeat color duplex examination for arterial and venous system was performed, search for any associated disease that may alter the immune system e.g. malignancy... etc., and lab test for possibility of collagen disorder including; ESR, CRP Quantitative, ANA. Anti Ds DNA, Rheumatoid factor, Rose Waller, Anti Ro [SSA], Lupus anticoagulant, ANCA, Viral markers: HCV antibody and H85 antigen. Immunosuppressive therapy was started in the form of combination of Prednisolone, Methotrexate, and Azathioprin, and observation of the ulcer healing
Results: Repeat color duplex for new perforator incompetence was positive in 16 [94.1%] of the 17 persistent venous ulcer. Among those 16 patients repeated petforator ligation with development of other new perforator necessitated surgery repetition. Each time, there was partial ulcer improvement followed by deterioration. At the end, all of the cases had no new perforators at the time of study enrollment. Colour duplex of arterial system Showed patent lower limb arterial system in all cases. Overall incidence ofpersistence venous ulcer in the study Was 17/630 cases [2.69%]. Malignancy detected in two of the study cases; follicular cancer thyroid and 'hyelaproliferative disorder. ESR and CRP quantitative were raised in all cases, some patients had more than one positive result. Response to immunosuppressive therapy, prednisolone + methotroxate + Azathioprin] an ulcer healing was complete in 5 [29.4%], and partial in 12 [70.6%] cases
Conclusion: Leg ulcers in chronic venous insuj72ciency patients associated with vasculitis are due to triggered factors which activate the immunopathological mechanisms. They are typically chronic, slow to heal, and commonly recur.
ABSTRACT
A significant proportion of patients with acute myeloid leukemia who achieve remission subsequently experience frank relapse of their disease, and their ultimate prognosis is typically poor. Investigation of minimal residual disease has proven to be a valuable tool for predicting impending relapse before clinical and hematologic manifestations. The aim of this study was the detection of minimal residual disease in AML patients fallowing complete remission [CR] using high resolution chromosome banding technique of bone marrow specimens and their implication on clinical course of the disease. The present study included 27 patients with de novo AML as initial series. Their diagnosis was based on morphological and immunophenotypical criteria. Among these, 15 patients [55.5%] achieved morphologic complete remission, whom the present study was done on that cases for one year of follow up for detection of relapse; 3 patients were M1, 5 were M2, 2 were M3, 2 were M4 and 3 were M5. High resolution banding technique of bone marrow cells revealed that seven patients [7/15; 47%] had cytogenetic abnormalities; 3 had chromosomal translocations [t[6;9], t[15;17], t[l;8]], one with chromosome 5 monosomy, one deletion [del [7q]], one chromosome duplication [dup [13q]] and one with trisomy 8. During the follow up period, 71% [5/7] of cases with cytogenetic abnormalities relapsed, while 37.5% [3/8] of cases with normal cytogenetics relapsed. There was a significant difference between those who relapsed and had cytogenetic abnormalities and those who relapsed and had normal cytogenetics in their response to treatment. In conclusion, high resolution chromosome banding technique of bone marrow cells is valuable in the detection of minimal residual disease in AML and therefore patients at high risk of relapse could be identified for better management