ABSTRACT
The aim of this study was to evaluate the patients with squamous cell carcinoma [SCC] of the lip in terms of age, sex, tumor localization, tumor size, histopathological subtype, lymph node metastasis, and recurrence rates. Forty patients with lip SCC were included in the study. A large majority of the patients were within the age range of 61-79 years [50 percent]. SCC was located in the lower lip in 35 [87.5 percent] patients. The average diameter of the tumor was 2.15 cm [range 0.4-7 cm]. The most common histopathological subtypes were well differentiated [n = 15, 37.5 percent] and microinvasive SCC [n = 12, 30 percent]. All patients underwent tumor excision with safe surgical margins. In six patients [15 percent] with local recurrence after total excision, two SCCs were localized on the right side of the lower lip, two on the left side of the lower lip, and two in the middle of the lower lip. Four of them were well-differentiated SCC, one was poorly differentiated SCC, and one was moderately differentiated SCC. Cervical lymph node metastasis was detected in two [33.3 percent] patients with recurrence. SCCs located on the lower lip were more aggressive than basal cell carcinomas, which were quite common in the head and neck regions. Despite total excision, patients should be followed up closely in terms of recurrence and metastasis. Tumor localization, size, and submandibular lymph nodes should be taken into account in addition to the histopathological subtype of tumor at the time of diagnosis.
ABSTRACT
This study aimed to assess the diagnostic value of thiol-disulfide homeostasis in patients with acute appendicitis [AA]. A total of 43 patients diagnosed with acute appendicitis in the emergency department and 59 healthy individuals were evaluated. Age, gender, white blood cell count, and thiol-disulfide homeostasis parameters [native thiol, total thiol, disulfide, disulfide/native thiol, native thiol/total thiol, and disulfide/total thiol ratios] were compared between groups. Thiol-disulfide homeostasis was determined using a newly developed method by Erel and Ne?elio?lu. White blood cell counts were statistically significantly higher in the AA group, but no significant difference [P = 0.742] was found between native thiol, total thiol, and disulfide levels of the patient and control groups. Also, no statistically significant difference was observed in disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios [P = 0.117] between groups. This was thought to be a result of early diagnosis of AA in patients at the emergency department. Hence, the inflammatory response did not increase significantly at the time of diagnosis
ABSTRACT
The aim of this study was to explore the compatibility of clinical prediagnosis and histopathological diagnosis of skin punch biopsies at the Pathology Department of Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Turkey. Several factors may change the appearance of a typical lesion because the skin is open to the external environment, and clinical diagnoses may be difficult. As a result, the histopathological assessment of skin punch biopsies and the support given by clinicians to the pathologist are extremely important. Whole punch biopsy diagnoses, which were evaluated at the department between the years 2006 and 2015, were grouped according to the inflammatory reaction patterns determined and described in Weedon's Textbook of Dermatopathology. Subsequently, the compatibility rates of clinical prediagnosis were studied, focusing especially on the first three prediagnoses. A total of 2967 punch biopsies were evaluated at the department between the years 2006 and 2015; 93.09% were diagnosed with inflammatory dermatosis, and 6.9% with tumors. The compatibility rate between clinical prediagnosis and pathological diagnosis was 85.77%; 65.75% of the cases were compatible with the first three prediagnoses. The compatibility rate of inflammatory dermatosis was 93.09%.The most common compatibility with prediagnosis was seen in epidermal maturation and keratinization and elastic tissue lesions with a rate of 100%. Although performing a skin biopsy is easy, histopathological evaluation of the skin has not been used commonly. In fact, it is recommended that skin biopsy should be performed in cases with possible neoplasia, bullous diseases, or dermatosis, which have not been clinically diagnosed. In these cases, clinicopathological correlation is important to reach a true diagnosis. This study aimed to determine mutual contributions of clinicians and pathologists by evaluating clinicopathological compatibility rates