ABSTRACT
Endothehelial dysfunction. thrombogenesis and inflammation were studied as possible mechanisms in pathogertesis of cardic syndrome-X through monitoring plasma endothelin-1 fibrinogen, vWF and CRP in patients with typical chest pain, positive stress ECG[clinical and ECG evidence of ischemia] and normal coronary angiography. The aim of this study is to evaluate plasma concentration of enclothelin-1 and other factors in patients with typical angina pectoris and angiographically normal coronary arteries. This study included 50 patients complained of typical chest pain [group A], Another group of 20 healthy subjects were studied as control group [group B]. Exercise test and coronary angiography were performed for all patients. Patients showing positive exercise ECG and having normal coronary arteries were selected. Blood samples were collected and examined for endothelin-1, fibrinogen, CRP and vWF. Endotheline-l fibrinogen, CRP and vWF were found to be significantly raised in that group of patients with syndrome-X in comparison with the control group, so they could predict and confirm diagnosis in patients with syndrome-X. CRP, vWF fibrinogen and ET-1 in that order were significantly high in patients with syndrome-X. Thus assessment of their levels in serum may be highly needed to fulfill the diagnosis of cardiac syndrome-X