[Production, formulation, quality control and primary biological studies of [18F]KF for skeletal PET scanning]

[[18]F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water [[18O]H2O>95%] with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable form. Pre-clinical investigations and biological controls were performed to determine radioisotope distribution in laboratory rats, thus suitable information was gathered for imaging in humans. This radiopharmaceutical was proved to be quite safe and of high quality as a result of testing in laboratory rats

Screening for hepatitis B and C in surgical patients

Screening for hepatitis in pre-operative assessment of patients is not the usual practice. The aim of this study was to evaluate the frequency of hepatitis B and C disease in patients coming to hospital for elective surgery. Design: Descriptive study. Place and Duration: Study was conducted at Ziauddin Medical University Hospital between January 2001 to December 2002. Patients And All patients admitted electively for surgical procedure were screened for Hepatitis B and C before surgery. Latex method was first applied for immediate results and later reconfirmation by the ELISA technique in seropositive patients. In our study a total of 411 patients were screened for hepatitis. There were 179 males and 232 females. Out of 46 seropositive males, 27 were hepatitis B positive and 19 were hepatitis C positive and out of 28 seropositive females, 9 were hepatitis B and 19 were hepatitis C positive. Frequency of hepatitis B and C is high in elective surgical patients

Dependence of quality of thallium - 201 on irradiation data

Thallium-201 is produced through 203Tl [p, 3n] 201pb 201Tl reaction by cyclotron. This radioisotope has known as one of the cyclotron radioisotopes which is used for myocardial perfusion in the coronary artery disease, Tl-201 after chemical purification and quality control in the form of 201Tl-chlorid is ready to send to the hospitals. In this work the effect of the proton energy on quality of Tl-201, was studied. Radionucleidic purity was determined by high purity Ge [HPGe] detector Gamma spectrometer, in production time and after one half-life [73h]. The targets were coated with Enriched Thallium-203 [97%]. The Variation of thickness of targets was 18.3 +/- 1.3micro m. The different energies of bombardment on quality of Tl-201 and Tl-200, Tl-202, and Pb-203 [as impurity] were studied. The results have shown that optimum energy for proton was 28.5 MeV. The variation energy of bombardment can change the purity of Tl-201 but all results were in the standard range according to the United States Pharmacopoeia [USP] and European Pharmacopoeia