immune status of human persistent pyuria associated K.pneumoniae

Fifteen human persistent pyuria patients were diagnosed and investigated for their infection nature and immune status. They were associated with K.pneumoniae. The median concentrations for the: total serum protein, total serum globulin, mucosal globulin, serum IgG, IgM and IgA were higher and slightly higher than normal control subjects for immunoreactive and immunocompromised persistent pyuria patients respectively. The specific anti K pneumoniae circulating and mucosal agglutinins were 360 and36 respectively in immunoreactive subjects as well as they were 200 and 40 respectively for immunocompromized patients. The leucocyte inihibitory factors were as that of normal subjects. Thus, K. pneurnoniae immunodominant epitope is being of T-independent type and/or as B cell rnitogen, both at mucosal and systemic immune responses

immunology of pseudomonal human persistent pyuria

Pseudomonas aeruginosa was diagnosed in association with human persistent pyuria. It was noted among immunoreactive and immunocompromized patients. The test patient showed high; total serum protein, total circulating globulin and high mucosal globulin concentrations than those of normal subjects. The immunoglobulin concentration for the classes IgG IgM and IgA were higher than those normal subjects. The albumin - globulin ratio was lower than those of normal subjects. Circulating anti. Pseudomans aeruginosa specific agglutinins were of titer median value of 400 mucosal specific agglutinins, however, they were with median titer values of 40. in immunreactive patients. While they were of titer median values of 240, and 40 in the immunocomproruized patients. Likewise significant migration inhibition index LIF were noted in peripheral blood leukocytes and Mucosul leucocytes in immunreactive and nonsignificant in the immunocompromized patient. This can be due to the presence of an immunodominant T dependent and/or T independent epitopes