1.
Indian J Exp Biol
;
1992 Jul; 30(7): 611-4
Article
in English
| IMSEAR
| ID: sea-57508
ABSTRACT
Animals pretreated with cromakalim (1 mg/kg,po) along with isoproterenol (85 mg/kg,sc) showed less myocardial degenerative changes on histopathological examinations when compared with those treated with isoproterenol alone. Cromakalim's beneficial effects on myocardium were in dose-dependent manner. Administration of cromakalim (po) lowered significantly the serum LDH and SGOT and depleted intracytoplasmic glycogen as demonstrated by periodic schiff staining procedure. Increase in blood clotting time was highly significant (P less than 0.001). The results suggest cardioprotective effect of cromakalim in isoproterenol induced myocardial infarction.
Subject(s)
Animals , Aspartate Aminotransferases/drug effects , Benzopyrans/pharmacology , Blood Coagulation/drug effects , Cromakalim , Female , Glycogen/metabolism , Isoproterenol , L-Lactate Dehydrogenase/blood , Leukocyte Count/drug effects , Male , Myocardial Infarction/chemically induced , Myocardium/pathology , Pyrroles/pharmacology , Rats , Vasodilator Agents/pharmacology , Verapamil/pharmacology
2.
Article
in English
| IMSEAR
| ID: sea-18081
3.
Article
in English
| IMSEAR
| ID: sea-19851
Subject(s)
Animals , Astrocytes/pathology , Brain/pathology , Brain Edema/etiology , Female , Macaca mulatta , Male , Neurons/pathology , Oligodendroglia/pathology
4.
Article
in English
| IMSEAR
| ID: sea-24184
Subject(s)
Animals , Blood Pressure , Brain Diseases/physiopathology , Dura Mater , Electroencephalography , Female , Haplorhini , Heart Rate , Intracranial Pressure , Macaca , Male , Respiration
5.
Article
in English
| IMSEAR
| ID: sea-23225