ABSTRACT
Physical exercise training (PET) has been considered an excellent non-pharmacological strategy to prevent and treat several diseases. There are various benefits offered by PET, especially on the immune system, promoting changes in the morphology and function of cells, inducing changes in the expression pattern of pro and anti-inflammatory cytokines. However, these changes depend on the type, volume and intensity of PET and whether it is being evaluated acutely or chronically. In this context, PET can be a tool to improve the immune system and fight various infections. However, the current COVID-19 pandemic, caused by SARS-CoV-2, which produces cytokine storm, inducing inflammation in several organs, with high infection rates in both sedentary and physically active individuals, the role of PET on immune cells has not yet been elucidated. Thus, this review focused on the role of PET on immune system cells and the possible effects of PET-induced adaptive responses on SARS-CoV-2 infection and COVID-19.
Subject(s)
Humans , Pandemics , COVID-19 , Exercise , Cytokines , SARS-CoV-2 , Immune SystemABSTRACT
Abstract INTRODUCTION: Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection. METHODS: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial. RESULTS: Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels. CONCLUSIONS: BCG responsiveness does not affect protection against atopy.
Subject(s)
Humans , Male , Female , Immunoglobulin E/blood , BCG Vaccine/immunology , Immunization, Secondary , Interferon-gamma/biosynthesis , Time Factors , Immunoglobulin E/immunology , Skin Tests , Down-Regulation , HypersensitivityABSTRACT
O presente trabalho faz uma reflexão sobre a construção do campo da Biossegurança, apresenta sua abrangência, os complexos temas tratados e sua perspectiva interdisciplinar. O objetivo desse campo é propor ações capazes de prevenir e controlar riscos de agravos à saúde ambiental e humana, respondendo aos desafios teóricos e práticos impostos pelas constantes mudanças no mundo, decorrentes das intervenções humanas sobre a natureza, mediadas pelos avanços científicos e tecnológicos. São abordadas questões que inserem a Biossegurança como ferramenta na busca de um modelo de desenvolvimento sustentável, resgatando a relação entre degradação ambiental, condições precárias de saúde e controle do surgimento e ressurgimento de doenças nas populações.
This work reflects on the development of the field of Biosafety. The scope of this field is presented, as well as its complex themes and its interdisciplinary perspective. The scope of this field is to propose actions capable of preventing and controlling the risk of worsening human and environmental health. This is done in order to provide alternatives to the theoretical and practical challenges posed by the rapid changes in the world, resulting from human intervention in nature and mediated by scientific and technological advances. We address questions that place Biosafety as a tool in the search for a model of sustainable development, establishing the relationship between environmental degradation, precarious health conditions, and control of the emergence and reemergence of diseases in populations.