Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add filters








Language
Year range
1.
Acta Pharmaceutica Sinica ; (12): 788-792, 2002.
Article in Chinese | WPRIM | ID: wpr-312048

ABSTRACT

<p><b>AIM</b>To investigate the chemical constituents of the rhizomes of Beesia calthaefolia native to China in order to obtain a more comprehensive understanding of its effective components.</p><p><b>METHODS</b>Compounds were isolated by column chromatography with silica gel. Their structures were elucidated by spectral analysis and chemical evidence. Compounds identified were subjected to pharmacological evaluation.</p><p><b>RESULTS</b>Two novel compounds were isolated and identified as (20S, 24S)-15 alpha-acetoxy-16 beta, 24; 20, 24-diepoxy-9, 19-cyclolanostane-3 beta, 25-diol-3-O-beta-D-xylopyranoside (I) and (20S, 24R)-15 alpha-acetoxy-9, 19-cyclolanostane-3 beta, 16 beta, 20, 24, 25-pentaol-3-O-beta-D-xylopyranoside (II), named beesioside O and beesioside P.</p><p><b>CONCLUSION</b>Compounds I and II are new compounds. Compounds I exhibited immunosuppressive activity and could inhibit angiogenesis as well as inhibit the proliferation of osteoblast. Compound II displayed remarkable inhibition activity against calcium channel receptor.</p>


Subject(s)
Animals , Mice , Angiogenesis Inhibitors , Chemistry , Pharmacology , Calcium Channel Blockers , Chemistry , Pharmacology , Immunosuppressive Agents , Chemistry , Pharmacology , Molecular Conformation , Molecular Structure , Plants, Medicinal , Chemistry , Ranunculaceae , Chemistry , Saponins , Chemistry , Pharmacology
2.
Chinese Journal of Biotechnology ; (12): 561-565, 2002.
Article in Chinese | WPRIM | ID: wpr-256164

ABSTRACT

Using Trichoderma as an indicative fungus, three antifungal proteins in Triticale Zhongsi 237 seed were purified and characterized. These protein components were considered to be a new Class II chitinase and two kinds of beta-1, 3-glucanases. Chitinase molecular mass was 30.5 kD and enzyme activity was maximal at pH 6.0 and 37 degrees C. Two beta-glucanases molecular masses were 51 kD and 23 kD. N-terminal amino acid sequences of Triticale chitinase share high homology with barley chitinase. In some conditions, the chitinase and beta-glucanases all had strong antifungal activity and were able to inhibit Trichoderma growth synergistically. Moreover, the chitinase and beta-1, 3-glucanases were able to inhibit powdery mildew growth on detached susceptible wheat leaves.


Subject(s)
Antifungal Agents , Pharmacology , Chitinases , Pharmacology , Glucan 1,3-beta-Glucosidase , Molecular Weight , Plant Proteins , Pharmacology , Seeds , Chemistry , Trichoderma , Triticum , Chemistry , Microbiology , beta-Glucosidase , Pharmacology
SELECTION OF CITATIONS
SEARCH DETAIL