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Indian J Physiol Pharmacol ; 1982 Apr-Jun; 26(2): 147-51
Article in English | IMSEAR | ID: sea-108729

ABSTRACT

The uterotropic effect of clofibrate and phenylbutazone was studied in immature female rats. A significant increase in the uterine wet weight was observed following clofibrate and phenylbutazone administration. Clofibrate but not phenylbutazone synergized with the uterotropic effect of ethinyl-oestradiol. Phenylbutazone pretreatment significantly decreased the pentobarbitone sleeping time. The uterotropic effect of clofibrate and phenylbutazone might involve displacement of 17-beta oestradiol (or ethinyl oestradiol) from plasma albumin binding sites in rats.


Subject(s)
Animals , Clofibrate/pharmacology , Drug Synergism , Estrogens , Ethinyl Estradiol/pharmacology , Female , Organ Size/drug effects , Pentobarbital/antagonists & inhibitors , Phenylbutazone/pharmacology , Rats , Sleep/drug effects , Uterus/drug effects
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