ABSTRACT
This study aimed to elucidate cortical mechanisms involved in anticipatory actions when 23 healthy right-handed subjects had to catch a free falling object through quantitative electroencephalogram (qEEG). For this reason, we used coherence that represents a measurement of linear covariation between two signals in the frequency domain. In addition, we investigated gamma-band (30-100 Hz) activity that is related to cognitive and somatosensory processes. We hypothesized that gamma coherence will be increase in both parietal and occipital areas during moment after ball drop, due to their involvement in manipulation of objects, visuospatial processing, visual perception, stimuli identification and attention processes. We confirmed our hypothesis, an increase in gamma coherence on P3-P4 (t= -2.15; p=0.033) and PZ-OZ (t= -2.16; p=0.034) electrode pairs was verified for a paired t-test. We conclude that to execute tasks involving anticipatory movements (feedforward mechanisms), like our own task, probably, there is no need of a strong participation of visual areas in the process of information organization to manipulate objects and to process visuospatial information regarding the contact hand-object.
Este estudo teve como objetivo elucidar os mecanismos corticais envolvidos em ações antecipatórias quando 23 indivíduos saudáveis destros tinham que apreender um objeto em queda livre, através da eletroencefalografia quantitativa (EEGq). Por esta razão, usamos a coerência que representa a covariação linear entre dois sinais no domínio da frequência. Além disso, investigamos a atividade da banda gama (30-100 Hz), que está relacionada à processos cognitivos e somato-sensoriais. Nossa hipótese é que a coerência de gama estará aumentada em ambas as áreas parietais e occipitais durante o momento pós-queda da bola, devido ao seu envolvimento na manipulação de objetos, processamento visuo-espacial, percepção visual, identificação de estímulos e processos de atenção. Confirmamos nossa hipótese. Um aumento de coerência em gama nos pares de eletrodos P3-P4 (t= -2,15; p=0,033) e PZ-OZ (t= -2,16; p=0,034) foi verificado por teste-t pareado. Conclui-se que, para executar tarefas que envolvem movimentos de antecipação (mecanismos de retro-alimentação) como a nossa própria tarefa, provavelmente, não há necessidade de forte participação de áreas visuais no processo de organização da informação como para manipular objetos e processar a informação visuo-espacial no contato mão-objeto.
Subject(s)
Adult , Female , Humans , Male , Electroencephalography/methods , Functional Laterality/physiology , Psychomotor Performance/physiology , Visual Perception/physiology , Brain Mapping , Occipital Lobe/physiology , Parietal Lobe/physiologyABSTRACT
The effect of physical exercise on the treatment of depressive elderly adults has not been investigated thus far in terms of changes in cortical hemispheric activity. The objective of the present study was to identify changes in depressive symptoms, quality of life, and cortical asymmetry produced by aerobic activity. Elderly subjects with a diagnosis of major depressive disorder (DSM-IV) were included. Twenty patients (70 percent females, 71 ± 3 years) were divided into an exercise group (pharmacological treatment plus aerobic training) and a control group (undergoing pharmacological treatment) in a quasi-experimental design. Pharmacological treatment was maintained stable throughout the study (antidepressants and anxiolytics). Subjects were evaluated by depression scales (Beck Depression Inventory, Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale) and the Short Form Health Survey-36, and electroencephalographic measurements (frontal and parietal alpha asymmetry) before and after 1 year of treatment. After 1 year, the control group showed a decrease in cortical activity on the right hemisphere (increase of alpha power), which was not observed in the exercise group. The exercise group showed a significant decrease of depressive symptoms, which was not observed in the control group. This result was also accompanied by improved treatment response and remission rate after 1 year of aerobic exercise associated with treatment. This study provides support for the effect of aerobic training on alpha activity and on depressive symptoms in elderly patients. Exercise facilitates the treatment of depressive elderly adults, leading to clinical and physical improvement and protecting against a decrease in cortical activity.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Alpha Rhythm , Depressive Disorder, Major/therapy , Exercise Therapy/methods , Quality of Life , Anti-Anxiety Agents/therapeutic use , Antidepressive Agents/therapeutic use , Combined Modality Therapy , Depressive Disorder, Major/psychology , Electroencephalography , Follow-Up Studies , Psychiatric Status Rating ScalesABSTRACT
An interesting fact about language cognition is that stimulation involving incongruence in the merge operation between verb and complement has often been related to a negative event-related potential (ERP) of augmented amplitude and latency of ca. 400 ms - the N400. Using an automatic ERP latency and amplitude estimator to facilitate the recognition of waves with a low signal-to-noise ratio, the objective of the present study was to study the N400 statistically in 24 volunteers. Stimulation consisted of 80 experimental sentences (40 congruous and 40 incongruous), generated in Brazilian Portuguese, involving two distinct local verb-argument combinations (nominal object and pronominal object series). For each volunteer, the EEG was simultaneously acquired at 20 derivations, topographically localized according to the 10-20 International System. A computerized routine for automatic N400-peak marking (based on the ascendant zero-cross of the first waveform derivative) was applied to the estimated individual ERP waveform for congruous and incongruous sentences in both series for all ERP topographic derivations. Peak-to-peak N400 amplitude was significantly augmented (P < 0.05; one-sided Wilcoxon signed-rank test) due to incongruence in derivations F3, T3, C3, Cz, T5, P3, Pz, and P4 for nominal object series and in P3, Pz and P4 for pronominal object series. The results also indicated high inter-individual variability in ERP waveforms, suggesting that the usual procedure of grand averaging might not be considered a generally adequate approach. Hence, signal processing statistical techniques should be applied in neurolinguistic ERP studies allowing waveform analysis with low signal-to-noise ratio.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Evoked Potentials/physiology , Language , Reaction Time/physiology , Speech Perception/physiology , Brazil , Data Interpretation, Statistical , Electroencephalography , SemanticsABSTRACT
Caffeine is the most consumed psychoactive substance in the world. The effects of caffeine have been studied using cognitive and motor measures, quantitative electroencephalography (qEEG) and event-related potentials. However, these methods are not usually employed in combination, a fact that impairs the interpretation of the results. The objective of the present study was to analyze changes in electrophysiological, cognitive and motor variables with the ingestion of caffeine, and to relate central to peripheral responses. For this purpose we recorded event-related potentials and eyes-closed, resting EEG, applied the Stroop test, and measured reaction time. Fifteen volunteers took caffeine (400 mg) or placebo in a randomized, crossover, double-blind design. A significant reduction of alpha absolute power over the entire scalp and of P300 latency at the Fz electrode were observed after caffeine ingestion. These results are consistent with a stimulatory effect of caffeine, although there was no change in the attention (Stroop) test or in reaction time. The qEEG seems to be the most sensitive index of the changes produced by caffeine in the central nervous system since it proved to be capable of detecting changes that were not evident in the tests of cognitive or motor performance.
Subject(s)
Adult , Female , Humans , Male , Caffeine/pharmacology , Central Nervous System Stimulants/pharmacology , Central Nervous System/drug effects , Cognition/drug effects , Electroencephalography/drug effects , Psychomotor Performance/drug effects , Analysis of Variance , Cross-Over Studies , Double-Blind Method , Electrophysiology , /drug effects , Reaction TimeABSTRACT
O potencial evocado auditivo de média latência (MLAEP) tem sido empregado na avaliação do nível anestésico, sendo usual a análise morfológica (AEPidx - Indice de Potencial Evocado Auditivo, e DT - Distância Taxonômica). Neste trabalho, técnicas de detecção objetiva de respostas no domínio da freqüência (MSC - Magnitude Quadrada da Coerência, e CSM - Medida de Sincronismo de Componentes) foram avaliadas a partir de EEG sob estimulação auditiva. Dez voluntários foram estimulados com cliques repetitivos (7,645 Hz, nível de pressão sonora de 75 dB SPL), sendo EEG adquirido na derivação Vértex - Lobo Auricular durante 10 min sem administração de anestésico e dois períodos consecutivos de infusão contínua de propofol (3 mg/Kg/h, sedação, e 9 mg/Kg/h, anestesia) de 45 min cada. O instante de perda de consciência foi estimado com base no pressionamento de uma maniqueta em resposta a estímulos luminosos a cada 15 s. MSC e CSM permitem a inferência estatística de ausência de resposta auditiva (valor crítico, para e.g. alfa = 1 por cento) ao longo do processo anestésico. Além disso, MSC() e CSM() se reduzem durante a infusão (mais expressivamente na anestesia), tendo maior concordância (diagramas de Bland-Altman) com os resultados da maniqueta que AEPidx e DT, e maior equivalência (Wilcoxon Signed-Rank Test, alfa = 5 por cento) que DT.
Subject(s)
Propofol , Electroencephalography , Evoked Potentials, Auditory , Anesthesia , Electrophysiology , Acoustic Stimulation/instrumentation , Acoustic Stimulation/methods , Reaction Time/physiologyABSTRACT
Uma placa processadora digital de sinais (DSP), com o TMS320C30, em conjunto com um PC foi empregada na modelagem autoregressiva (AR) de sinais EEG. O sistema PC-DSP mostrou-se capaz de realizar a análise espectral destes sinais com tempo de processamento compatível com monitoração em tempo real do espectro de 16 canais EEG.