ABSTRACT
To explore influence of exercise rehabilitation therapy on inflammatory factor levels and cardiac func‐tion in patients with chronic heart disease (CHD).Methods :A total of 92 CHF patients of our department from Jun 2016 to May 2018 were randomly and equally divided into routine treatment group and exercise rehabilitation group (received ex‐ercise rehabilitation training based on routine treatment group ) ,both groups were intervened for six months .Cardiac func‐tion ,6min walking distance (6MWD) ,levels of inflammatory factors ,quality of life (QOL) before and after treatment were observed and compared between two groups .Results :Compared with routine treatment group after six months ,there were significant reductions in left ventricular end diastolic volume [LVEDV ,(61.26 ± 8.03) ml vs.(55.77 ± 7.75) ml] , left ventricular end systolic volume [LVESV ,(54.89 ± 6.15) ml vs.(51.36 ± 4.99) ml] ,levels of CRP [(21.41 ± 4.14) ng／ml vs.(18.18 ± 4.22) ng／ml] ,TNF‐α [ (18.46 ± 4.69) ng／ml vs.(15.67 ± 3.37) ng／ml] ,IL‐6 [ (80.09 ± 14.47) ng／ml vs.(71.88 ± 16.16) ng／ml] ,score of Minnesota living with heart failure questionnaire [ (49.50 ± 6.91) scores vs. (46.74 ± 5.12) scores] ,and significant rise in LVEF [ (43.11 ± 4.59)% vs.(45.33 ± 5.58)%] and 6MWD [ (265.70 ± 12.37) m vs.(336.89 ± 11.23) m] in exercise rehabilitation group , P＜0.05 or ＜0.01. Conclusion :Exercise rehabilita‐tion therapy can significantly improve inflammatory factor levels ,cardiac function and QOL ,and reduce rehospitalization rate within six months in CHF patients .
ABSTRACT
As a member of the HSP90 family, heat shock protein (HSP) Gp96 is one of the most abundant proteins in the endoplasmic reticulum (ER), which displayed important molecular chaperones function in cells. Gp96 can stimulate the production of cytokines by activating the antigen presentation cells (such as dendritic cell, et al) in innate immunity. It is capable of eliciting an antigen-specific cytotoxic T lymphocyte (CTL) immune response to eliminate pathogens and tumors by facilitating antigen cross-presentation in adaptive immunity. Gp96 is also an ideal adjuvant in many recent researches. Here, we review the progress that addresses the role of biological characteristics, immunogenic mechanism that may be involved in the induction of anti-infection immune response and antitumor immunity, which may guide the new vaccine strategies with the knowledge of Gp96-antigen complexes.