ABSTRACT
Objective: To evaluate the effects of 20 weeks of resistance and concurrent training on psychotic and depressive symptoms, quality of life outcomes, and serum IGF-1, IGFBP-3, and brain-derived neurotrophic factor (BDNF) concentrations in patients with schizophrenia. Methods: In this blind, randomized controlled clinical trial, 34 patients with schizophrenia were assigned to one of three groups: control (CTRL, n=13), resistance exercise (RESEX, n=12), or concurrent exercise (CONCEX, n=9). Symptoms, quality of life, strength, and other variables were assessed. Results: A significant time-by-group interaction was found for the RESEX and CONCEX groups on the Positive and Negative Syndrome Scale (PANSS) total score for disease symptoms (p = 0.007), positive symptoms (p = 0.003), and on the arm extension one-repetition maximum (1RM) test (p = 0.016). In addition, significant improvements on negative symptoms (p = 0.027), on the role-physical domain of the Short Form-36 Health Survey (p = 0.019), and on the chest press 1RM test (p = 0.040) were observed in the RESEX group. No changes were observed for the other variables investigated. Conclusions: In this sample of patients with schizophrenia, 20 weeks of resistance or concurrent exercise program improved disease symptoms, strength, and quality of life. ClinicalTrials.gov: NCT01674543.
Subject(s)
Adolescent , Adult , Humans , Male , Middle Aged , Young Adult , Exercise Therapy/methods , Resistance Training/methods , Schizophrenia/rehabilitation , Analysis of Variance , Antipsychotic Agents/therapeutic use , Brain-Derived Neurotrophic Factor/blood , /blood , Insulin-Like Growth Factor I/analysis , Muscle Strength/physiology , Quality of Life , Schizophrenia/physiopathology , Single-Blind Method , Time Factors , Treatment OutcomeABSTRACT
OBJETIVOS: Avaliar o equilíbrio, a coordenação e a agilidade dos idosos submetidos a exercícios físicos. MÉTODOS: 61 idosos do gênero masculino, com idades entre os 60-75 anos, designados aleatoriamente para um grupo de exercícios resistidos com carga progressiva (n=39) ou para um controle submetido a exercícios sem carga (n=22). O grupo exercício resistido participou de um programa de 24 semanas, com 3 visitas por semana, em dias não consecutivos. Foram avaliados após o término do treinamento, pela Escala de Equilíbrio de Berg, do Teste de Tinetti e do Timed UP & GO. RESULTADOS: Comparando-se os dois grupos verificou-se um melhor desempenho estatisticamente significativo para o grupo experimental em relação ao controle para os testes Timed "Up & Go". (p=0,02) e para o Tinetti Total (p=0.046) e para o Tinetti marcha (p=0.029). Desta forma, não encontramos diferença na Escala de Equilíbrio de Berg e no teste de Tinetti equilíbrio. CONCLUSÃO: O programa de treinamento de força durante 24 semanas mostrou-se favorável na melhora dos desempenhos funcional e motores de idosos.
OBJECTIVES: To evaluate balance, coordination and agility of older subjects submitted to physical exercise. METHODS: 61 male older subjects, aged between 60-75 years, randomly assigned to a resisted exercises with gradual load (n=39) group or to a control group submitted to exercise without load (n=22). The resisted exercise group participated in a 24 week-program, with 3 weekly visits, in not consecutive days. After the training ending, they were evaluated through the Berg Balance Scale and the Tinetti and Timed UP & GO tests. RESULTS: Comparing the two groups, better statistical significant performance was verified for the experimental group for the Timed "Up & Go" (p=0.02), for the Total Tinetti (p=0.046) and for the Tinetti gait tests (p=0.029). Therefore, we did not find difference in the Berg Balance Scale or in the Tinetti balance test. CONCLUSION: The strength training program during 24 weeks behaved favorable in improving functional and motor performance of older subjects.