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1.
Indian J Lepr ; 1993 Jan-Mar; 65(1): 23-7
Article in English | IMSEAR | ID: sea-54758
3.
Indian J Lepr ; 1985 Oct-Dec; 57(4): 780-9
Article in English | IMSEAR | ID: sea-54708

ABSTRACT

A computerized mathematical model of M. leprae populations during multiple drug therapy (MDT) was constructed. Relevant published information available to date was fed into it, and reasoned assumptions were made. From the model, it seems likely that MDT steadily selects bacteria resistant to the most powerful of the three drugs used: unless the individual bactericidal potencies of the drugs balance one another. If the drugs used have differing potencies, cure probably hinges on treatment being continued until all metabolically active bacteria are killed. Withdrawal of treatment before that could lead to relapse with bacteria resistant to the most powerful of the drugs used.


Subject(s)
Drug Resistance, Microbial , Drug Therapy, Combination , Humans , Leprosy/drug therapy , Mathematics , Models, Biological , Mutation , Mycobacterium leprae/drug effects , Software
4.
Indian J Lepr ; 1984 Apr-Jun; 56(2): 369
Article in English | IMSEAR | ID: sea-55094
5.
Indian J Lepr ; 1984 Jan-Mar; 56(1): 10-4
Article in English | IMSEAR | ID: sea-54783

ABSTRACT

In experiments at the Radda Barnen Research Laboratories of the SLR & TC Karigiri, the mouse footpad test was demonstrated to detect DDS-resistant M.leprae even if as few as 0.1% (1 in 1000) of the M. leprae tested were DDS-resistant. The mouse footpad test appears to be sensitive to minute proportions of drug-resistant bacilli in samples of M. leprae tested.


Subject(s)
Animals , Dapsone/pharmacology , Drug Resistance, Microbial , Mice , Mice, Inbred CBA , Microbial Sensitivity Tests/methods , Mycobacterium leprae/drug effects
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