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Braz. j. med. biol. res ; 23(8): 701-3, 1990. tab, ilus
Article in English | LILACS | ID: lil-92279

ABSTRACT

The present study analyzes the effects of indomethacin on the development of tolerance to the diuretic effect of ethanol. Male Wistar rats were with ethanol (2gKg-1 day-1) over a period of 4 weeks and the effect of ethanol on diuresis was assessed weekly. A significant tolerance to the diuretic effect of ethanol was detected after 3 weeks of treatment. However, rats treatment simultaneously with ethanol plus indomethacin (5mg/Kg, ip,, on alternate days) showed no tolerance to ethanol even after 4 weeks of treatment. The fact that indonethacin prevented the development of tolerance to the diuretic effect of ethanol but no influence on diuresis per se suggests that prostaglandins play a significant role in the mechanisms of tolerance to ethanol


Subject(s)
Rats , Animals , Diuresis/drug effects , Ethanol/antagonists & inhibitors , Indomethacin/pharmacology , Prostaglandins/physiology , Drug Tolerance , Rats, Wistar
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