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1.
Korean Journal of Obstetrics and Gynecology ; : 910-913, 2000.
Article in Korean | WPRIM | ID: wpr-88155

ABSTRACT

Ovarian myoma is a rare mesenchymal tumor, accounting for only 1% of benign ovarian neoplasm. These tumors only originate from smooth muscle on the walls of blood vessels in the cortical stroma, in the corpus luteum and in the ovarian ligaments at the point of attachment to the ovary. Most patients are asymptomatic and the tumors are usually found incidently during operations or at autopsies. Two cases of ovarian myoma experienced in our hospital recently are reported with a brief review of the literatures."


Subject(s)
Female , Humans , Autopsy , Blood Vessels , Corpus Luteum , Leiomyoma , Ligaments , Muscle, Smooth , Myoma , Ovarian Neoplasms , Ovary
2.
Korean Journal of Obstetrics and Gynecology ; : 2264-2269, 1999.
Article in Korean | WPRIM | ID: wpr-227079

ABSTRACT

OBJECTIVES: MDM-2 is an oncoprotein that inhibits p53 tumor suppressor protein. Amplication and over- expression of its protein have been observed in human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To elucidate the role of p53 and MDM-2 protein in cervical neoplasia we investigated the expression rates of MDM-2 and p53 protein in surgically resected specimens. METHEDS: Immunohistochemical studies using anti-p53 and anti-MDM-2 protein in the paraffin embedded section of 62 cases including cervical intraepithelial neoplasm(CIN) and invasive cervical cancer were performed. RESULTS: Expression rates of p53 protein were 25% in CIN I& CINII, 20% in CINIII, and 44% in invasive carcinoma, respectively. The MDM-2 protein were 33% in CIN I & CIN II, 16% in CIN III, and 48% in invasive carcinoma, respectively. There was no evident correlation between p53 positivity and MDM-2 positivity(p>0.05). However, correlation between MDM-2 negativity and p53 negativity was statistically significant(p=0.002) CONCLUSION: These data suggest that the expression of p53 protein is presumed to be necessarily correlated with MDM-2 protein expression in cervical neoplasia.


Subject(s)
Humans , Carcinogenesis , Paraffin , Proto-Oncogene Proteins c-mdm2 , Tumor Suppressor Protein p53 , Uterine Cervical Neoplasms
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