1.
Braz. j. med. biol. res
;
21(3): 603-5, Mar. 1988. tab
Article
in English
| LILACS
| ID: lil-60253
ABSTRACT
The present study examines the effect of diphenylhydantoin on the elicitation by K+ and propagation of spreading depression in chick retina preparations in vitro. A dose-related decrease in the velocity of propagation was observed, this effect being lessened by increasing the pH of the Ringer bathing the preparation. Changes in Ringer C1- concentration also altered the efficacy of the drug, higher concentrations enhancing and lower concentrations reducing efficacy. The threshold concentration of K+ necessary to elicit the reaction was elevated by dyphenylhydantoin