ABSTRACT
Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palmar-plantar erythrodysesthesia, diffuse follicular rash, intertrigo-like eruption, new formation of melanotic macules, stomatitis and radiation recall dermatitis. We present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin.
.Subject(s)
Aged , Female , Humans , Antibiotics, Antineoplastic/adverse effects , Doxorubicin/analogs & derivatives , Esophagitis/chemically induced , Hand-Foot Syndrome/etiology , Stomatitis/chemically induced , Doxorubicin/adverse effects , Esophagitis/pathology , Gastric Mucosa/drug effects , Hand-Foot Syndrome/pathology , Mouth Mucosa/drug effects , Multiple Myeloma/complications , Multiple Myeloma/drug therapy , Polyethylene Glycols/adverse effects , Stomatitis/pathologyABSTRACT
Immunoglobulin light chain amyloidosis is the most common acquired systemic amyloidosis. Its presentation is often insidious and progressive, which may delay diagnosis. The authors describe a rare case of immunoglobulin light chain amyloidosis in a 34-year-old man with scleroderma-like manifestation substantiated by multifarious laboratory investigations and the histopathologic feature of involved skin lesions stained with Congo red and crystal violet. This helps to maintain a high clinical suspicion of the disease when confronting similar skin presentation.