Anatomy of osterior antebrachial cutaneous nerve related to the lateral epicondyle and interepicondylar line / Anatomía del nervio cutáneo posterior del antebrazo relacionado con el epicóndilo lateral y la línea interepicondilar

Posterior antebrachial cutaneous nerve (PACN) is a branch of radial nerve supplying the skin of posterior forearm. Data regarding its anatomy remain insufficient especially the origin and number of branches. We dissected 101 upper extremities from 32 male and 20 female cadavers to expose the PACN. In all specimens, the nerve emerged from the deep fascia at the hiatus proximal to the interepicondylar line (IEL) with mean distances of 7.24 and 7.44 cm in males and females, respectively. Percentage of this distance to the arm length was 23.2 % and 26.1 % in males and females, respectively. After penetrating the deep fascia, the PACN coursed in the subcutaneous layer and crossed the IEL anterior to the lateral epicondyle (LE) in all cases. The mean distances from the crossing point to the LE along the IEL were 1.52 cm in males and 1.34 cm in females. Regarding the branches of PACN, at least 50 % of the specimens had up to 3 or 4 branches originating either proximal or distal to the hiatus. In two arms, one of these branches passed posterior to the LE. Moreover, there were communicating branches between the PACN and the lateral antebrachial cutaneous nerve in 9 specimens. Gender and side differences were found in some measurement parameters. These data are crucial for avoiding the PACN injury during surgical procedures around the elbow.

El nervio cutáneo posterior del antebrazo (NCPA) es un ramo del nervio radial que inerva la piel del antebrazo. Los datos acerca de su anatomía siguen siendo insuficientes en especial en cuanto a su origen y el número de ramos. Disecamos 101 miembros superiores de cadáveres pertenecientes a 32 hombres y 20 mujeres para exponer el NCPA. En todas las muestras, el nervio surgió de la fascia profunda en el hiato proximal a la línea interepicondilar (LIE) con distancias medias de 7,24 y 7,44 cm en hombres y mujeres, respectivamente. El porcentaje de esta distancia a la longitud del brazo fue 23,2 % y 26,1 % en hombres y mujeres, respectivamente. Después de penetrar la fascia profunda, el NCPA continuaba en el tejido subcutáneo y cruzaba la LIE anterior al epicóndilo lateral (EL) en todos los casos. Las distancias medias desde el punto de cruce del EL a lo largo de la LIE fueron 1,52 cm en hombres y 1,34 cm en mujeres. Con respecto a las ramos del NCPA, al menos 50 % de las muestras tenían hasta 3 o 4 ramos, ya fuesen proximales o distales al hiato. En dos de los brazos, uno de estos ramos pasó posterior al EL. Por otra parte, en 9 de las muestras se observó comunicación entre los ramos del NCPA y el nervio cutáneo antebraquial lateral. No se encontraron diferencias secundarias o de sexo en algunos parámetros de medición. Estos datos son esenciales para evitar las lesiones durante los procedimientos quirúrgicos alrededor del codo que involucren el NCPA.

Anatomy of the sural nerve related to calcaneal tendon, intermalleolar line and small saphenous vein / Anatomía del nervio sural en relación con el tendón calcáneo, la línea intermaleolar y la vena safena parva

Sural nerve (SN) courses from the posterior aspect of leg to the lateral side of ankle and foot. Anatomy of the SN is of clinical importance due to its involvement in nerve biopsy, nerve graft harvesting including injuries during calcaneal tendon repair. Despite substantial knowledge in the literature, more easily located landmarks and data regarding the symmetry are still needed. Ninety-eight lower extremities from 31 males and 18 females were dissected in this study. The SN originated from the union between the medial and lateral sural cutaneous nerves in 52.0 % of the legs. The distance from the union point to the intermalleolar line (IML) was 16.3±8.4 (SD) cm. The ratio of this distance to the fibular length (apex of head to lateral malleolus or LM) was 0.47±0.23 cm. In 84.7 % of the legs, the SN initially coursed medial to and then crossed the lateral border of calcaneal tendon at the distance of 8.4±2.1 cm above the IML. The ratio to the fibular length was 0.25±0.06 cm. At the level of IML, the SN was posterior to the most prominent part of the LM in 95.9 % of the legs with the distance of 2.6±0.5 cm. At the closest point, the SN was lateral to the small saphenous vein in 74.5 % of the legs and the distance from this point to the IML was 10.6±4.7 cm. The ratio to the fibular length was 0.31±0.14 cm. Side difference or asymmetry was observed in a substantial number of specimens. These data are crucial for not only localizing the SN during biopsy and graft harvesting but also avoiding the nerve injury during relevant surgical procedures.

El nervio sural (NS) transcurre por la región posterior de la pierna, el tobillo y el pie. La anatomía del NS es de importancia clínica durante la realización de una biopsia, el desarrollo de injerto de nervio, incluyendo lesiones del nervio durante la reparación del tendón calcáneo. A pesar del conocimiento sustancial en la literatura, aún se necesitan puntos de referencia más fáciles de localizar e información sobre la simetría. Noventa y ocho miembros inferiores de 31 hombres y 18 mujeres fueron disecados. El NS se originó a partir de la unión entre los nervios cutáneo sural medial y cutáneo sural lateral en el 52,0 % de las piernas. La distancia desde el punto de unión a la línea intermaleolar (IML) fue de 16,3±8,4 (SD) cm. La relación de esta distancia a la longitud de la fíbula (vértice de la cabeza al maléolo lateral o LM) fue de 0,47±0,23 cm. En el 84,7 % de las piernas, el NS se ubicó inicialmente medial y luego cruzó el margen lateral del tendón calcáneo a una distancia de 8,4±2,1 cm proximal a la IML. La relación de longitud de la fíbula fue de 0,25±0,06 cm. A nivel de la IML, el NS se localizaba posterior a la parte más prominente de la LM en el 95,9 % de las piernas, con una distancia de 2,6±0,5 cm. En el punto más cercano, el NS se localizaba lateral a la vena safena parva en 74,5 % de las piernas y la distancia desde este punto hasta la IML fue de 10,6±4,7 cm. La relación de longitud de la fíbula fue 0,31±0,14 cm. La diferencia entre los lados o asimetría se observó en un número considerable de ejemplares. Estos datos son esenciales no sólo para localizar el NS durante la biopsia y la realización del injerto sino también para evitar la lesión del nervio durante procedimientos quirúrgicos relevantes.

Medial antebrachial cutaneous nerve: anatomical relationship with the medial epicondyle, basilic vein and brachial artery / Nervio cutáneo antebraquial medial: relación anatómica con el epicóndilo medial, vena basílica y arteria braquial

Medial antebrachial cutaneous nerve (MACN) courses in the medial arm to provide sensory innervation to the medial forearm. Its anatomy has been partly described since data regarding its branching pattern and distances to adjacent landmarks are still lacking. The purpose of this study was to provide morphometric anatomy of the MACN with comparisons between sides and sexes. Ninety-six upper extremities from 26 males and 22 females were dissected. We found that up to 5 branches of MACN pierced the deep fascia with the maximum of 4 reaching the interepicondylar line (IEL). Presence of 2 and 3 branches was found in the majority of cases (> 80%). The distances from these branches to the landmarks varied considerably. In case of no branch, the mean distances to the medial epicondyle (ME) and brachial artery (BA) were approximately 1.5 cm while those to the basilic vein (BV) were 0.7 cm in both sexes. Regardless of the branching pattern, the MACN could pass over or close (within 0.5 cm) to the ME, BV and BA. Asymmetry in the branching pattern was found in 50% of specimens. Sex but not side differences were observed in some measurement parameters. These data are crucial for not only localizing the MACN during nerve block and graft harvest but also avoiding the nerve injury during surgical procedures.

El recorrido del nervio cutáneo antebraquial medial (NCAM) proporciona la inervación sensorial medial del antebrazo. Su anatomía se ha descrito en parte, porque los datos relativos a su patrón de ramificación y distancias a puntos de referencia adyacentes son insuficientes. El propósito de este estudio fue proporcionar datos morfométricos sobre la anatomía del NCAM, comparando entre lados y sexos. Se disecaron 96 miembros superiores de 26 hombres y 22 mujeres. Se encontró que 5 ramos del NCAM traspasaron la fascia profunda y llegaron 4 hasta la línea interepicondilar (LIE). Presencia de 2 y 3 ramos se encontró en la mayoría de los casos (>80%). Las distancias de estos ramos a los puntos anatómicos variaron considerablemente. En caso de ausencia de ramos, la distancia medial al epicóndilo medial (EM) y arteria braquial (AB) fueron de aproximadamente 1,5 cm, mientras que a la vena basílica (VB) fueron 0,7 cm en ambos sexos. Independientemente del patrón de ramificación, el NCAM podría pasar sobre o cerca (a menos de 0,5 cm ) del EM, VB y AB. Asimetría en el patrón de ramificación se encontró en 50% de las muestras. Diferencias en algunos de los parámetros de medición se observaron según sexo, pero no por lado. Estos datos son relevantes para localizar el NCAM durante el bloqueo del nervio y la toma de injertos, sino también para evitar la lesión del nervio durante los procedimientos quirúrgicos.

Sartorial branch of saphenous nerve: anatomical relationship with bony landmarks and great saphenous vein / Ramo sartorial del nervio safeno safeno: relación anatómica con puntos de referencia óseos y de la vena safena magna

Sartorial branch of saphenous nerve (medial crural cutaneous nerve) originates at the medial side of the knee and descends along the great saphenous vein (GSV) to innervate the medial aspect of the leg. Its anatomy is of concern in surgical procedures and anesthetic block. However, the measurement data related to palpable bony landmarks with comparison between sexes and sides are lacking. Dissection was done in 95 lower limbs from both sexes. We found that the nerve pierced the deep fascia alone in most cases (92.6%). This piercing point was always distal to the adductor tubercle with the distance of 5-6 cm which was 15% of the leg length (the distance between the adductor tubercle and medial malleolus). The nerve was 7 cm medial to the tibial tuberosity. At the mid-level of leg length, the nerve was slightly over 4 cm medial to the anterior tibial margin. The nerve terminally divided 7 cm proximal to the medial malleolus. Furthermore, the anatomical relationship between the nerve and the GSV was highly variable. The nerve was constantly anterior, posterior or deep to the GSV in 8.4%, 15.8% and 2.1%, respectively. Crossing between the two structures was observed in 57.9% of specimens and the distance to the medial malleolus was 18 cm. Symmetry was found in most parameters and significant gender differences were observed in some distances. These results are important for avoiding the sartorial nerve injury and locating the nerve during relevant procedures.

El ramo sartorial del nervio safeno (nervio cutáneo medial de la pierna) se origina en el lado medial de la rodilla y desciende a lo largo de la vena safena magna (VSM) para inervar la cara medial de la pierna. Su anatomía es motivo de preocupación en los procedimientos quirúrgicos y en el bloqueo anestésico. Sin embargo, los datos de medición relacionados con puntos de referencia óseos palpables y la comparación entre los lados y en ambos sexos son escasas. Se realizó la disección en 95 miembros inferiores de ambos sexos. Se encontró que el nervio perforó la fascia profunda en la mayoría de los casos (92,6%). Esta punta de perforación fue siempre distal al tubérculo del músculo aductor magno a una distancia de 5-6 cm, que representaba el 15% del largo de la pierna (la distancia entre el tubérculo del aductor magno y el maléolo medial). El nervio se localizaba 7 cm medial a la tuberosidad tibial. Al nivel del tercio medio en ambas piernas, el nervio estaba a una distancia un poco mayor a 4 cm medial al margen anterior de la tibia. El nervio se dividía 7 cm proximal al maléolo medial. Por otra parte, la relación anatómica entre el nervio y la VSM fue muy variable. El nervio era constantemente anterior, posterior o profundo a la VSM en 8,4%, 15,8% y 2,1%, respectivamente. Cruce entre las dos estructuras anatómicas se observó en el 57,9% de las muestras y la distancia hasta el maléolo medial fue de 18 cm. La simetría se encuentra en la mayoría de los parámetros y diferencias de sexo significativas se observaron en algunas distancias. Estos resultados son importantes para evitar la lesión del nervio sartorial y localizar el nervio durante los procedimientos pertinentes.

Anatomy of the facial nerve branching patterns, the marginal mandibular branch and its extraparotid ramification in relation to the lateral palpebral line.

Background: Surgery of face and parotid gland may cause injury to branches of the facial nerve, which results in paralysis of muscles of facial expression. Knowledge of branching patterns of the facial nerve and reliable landmarks of the surrounding structures are essential to avoid this complication. Objective: Determine the facial nerve branching patterns, the course of the marginal mandibular branch (MMB), and the extraparotid ramification in relation to the lateral palpebral line (LPL). Materials and methods: One hundred cadaveric half-heads were dissected for determining the facial nerve branching patterns according to the presence of anastomosis between branches. The course of the MMB was followed until it entered the depressor anguli oris in 49 specimens. The vertical distance from the mandibular angle to this branch was measured. The horizontal distance from the LPL to the otobasion superious (LPL-OBS) and the apex of the parotid gland (LPL-AP) were measured in 52 specimens. Results: The branching patterns of the facial nerve were categorized into six types. The least common (1%) was type I (absent of anastomosis), while type V, the complex pattern was the most common (29%). Symmetrical branching pattern occurred in 30% of cases. The MMB was coursing below the lower border of the mandible in 57% of cases. The mean vertical distance was 0.91±0.22 cm. The mean horizontal distances of LPL-OBS and LPLAP were 7.24±0.6 cm and 3.95±0.96 cm, respectively. The LPL-AP length was 54.5±11.4% of LPL-OBS. Conclusion: More complex branching pattern of the facial nerve was found in this population and symmetrical branching pattern occurred less of ten. The MMB coursed below the lower border of the angle of mandible with a mean vertical distance of one centimeter. The extraparotid ramification of the facial nerve was located in the area between the apex of the parotid gland and the LPL.

Ganglioside GM1 (porcine) ameliorates paclitaxel-induced neuropathy in rats.

BACKGROUND: Paclitaxel, an anti-neoplastic agent effective against several solid tumors, has several side effects including peripheral neuropathy. So far, there are no effective treatments for this complication. Monosialic acid ganglioside (GM1) has been shown to protect neurons against injuries and degeneration. However, its efficacy in the treatment of paclitaxel-induced neuropathy has not been verified. OBJECTIVE: To evaluate the effect of porcine GM1 on neurophysiological abnormalities in rats receiving paclitaxel. MATERIAL AND METHOD: Fifty-four Wistar rats were divided into control, vehicle for paclitaxel (Cremophor EL), paclitaxel, and paclitaxel + GM1 groups. Paclitaxel 16 mg/kg/week for five consecutive weeks was given intraperitoneally. Treatment with 30 mg/kg 5 days per week of GM1 was started 3 days prior to the first dose and continued until 3 days after the last dose of paclitaxel. Tail and hind paw thermal thresholds including tail motor nerve conduction velocity (MNCV) were measured prior to and after the start of treatments. Histopathology of the sciatic nerve was also examined. RESULTS: Paclitaxel alone induced thermal hypoalgesia and reduced tail MNCV Less severe abnormalities were also found with the vehicle. GM1 appeared to prevent the development of hypoalgesia and ameliorated the decreased MNCV without any evidence of Guillain-Barre Syndrome. Mild endoneurial edema and axonal degeneration in the sciatic nerve sections were seen in paclitaxel treated rats. Microtubule accumulation and activated Schwann cell were also presented in the paclitaxel treated groups. CONCLUSION: These data suggest that porcine GM1 may be useful in the prevention and treatment of paclitaxel-induced neuropathy. However the adverse effect of Cremophor EL should be of concern.

Surgical anatomy of fissures and foramina in the orbits of Thai adults.

BACKGROUND: The anatomy of orbital foramina appears to vary depending on the population studied Moreover; different data between sides and genders have been reported. OBJECTIVE: The present study was done to provide the morphometric data of the orbitalforamina related to side and gender in Thai subjects. MATERIAL AND METHOD: One hundred orbits from 50 adult dried skulls were used. Gender of each skull was identified and the distances from the constant landmarks to the foramina in the medial, superior; inferior and lateral walls were measured. RESULTS: In the medial wall, the mean distances from the anterior lacrimal crest to the optic canal (OC), anterior, and posterior ethmoidalforamina were 42.2, 23.5, and 36. 0 mm for both sides and genders, respectively. The average distances from the supraorbital notch/foramen in the roof to the superior orbital fissure (SOF), OC, and lacrimal foramen were 44.7, 40.0, and 33.6 mm, respectively. In the inferior wall, the distances from the infraorbital rim to the OC, inferior orbital fissure (IOF), and the posterior edge of roof of the infraorbital canal were 46.2, 21.7, and 12.3 mm, respectively. The distances from the frontozygomatic suture to the OC, SOF, IOF and LF were 46.9, 34.5, 24.0, and 27.2 mm, respectively. When compared to those of the previous reports, several considerable differences that may be of clinical importance were observed. Moreover, some distances were significantly different between sides or genders. CONCLUSION: The present results suggest that race, side, and gender should be concerned during the orbital surgery and the data are good references for Thai subjects.

Anatomic characteristics and surgical implications of the superficial radial nerve.

BACKGROUND: Superficial radial nerve (SRN) that lies superficially on the radial side of the distalforearm and dorsum of the hand, can be injured by various procedures. Thus, precise knowledge in its variation is crucial. OBJECTIVE: Since there were no such data in Thai population, provide the variation data of the SRN in Thai cadavers. This is likely to be more accurate when applied in Thailand. MATERIAL AND METHOD: The authors studied the branching pattern and the course of SRN in 40 Thai cadavers. RESULTS: The extra type, replacement of SR3 by a branch of the lateral antebrachial cutaneous nerve, was found (4.7%) and the incidences of other patterns were different from those of previous reports. Moreover; asymmetry and gender difference were also demonstrated. The authors observed the higher frequencies of the SRN lying over the snuff box and first dorsal compartment of the wrist compared to other reports. The distances to important landmarks were measured and the presented data were comparable to those of other studies with no significant differences between sides or genders. CONCLUSION: These findings suggest that the different variations of the SRN among various races should be concerned during the relevant procedures.

History and evolution of western medicine in Thailand.

Background: Western medicine entered into the Kingdom of Siam for the first time in Ayutthaya Period. In 1686, Chevalier de Forbin, a French military officer described a surgical operation in which the stomach and intestine of a patient were restored into the abdomen and the surgical wound closed by suturing, without complication. Soon after this the relationship between Thailand and Europe was severed until it was renewed in the Bangkok Period. Thailand’s first hospital was built in the province of Petchaburi in 1878. The first hospital built by the government of Thailand was Siriraj Hospital in 1887; and the Red Cross Society was founded in 1893. King Chulalongkorn Memorial Hospital was established in 1914. Chulalongkorn University was established with the Faculty of Medicine in 1916. In 1942, the Ministry of Public Health was established to regulate medical services and public health of the people of Thailand. Objective: To introduce the history and development of western medicine in Thailand.

Her Royal Highness Princess Maha Chakri Sirindhorn: her activities in humanity and medicine.

Her Royal Highness Princess Maha Chakri Sirindhorn, the Executive Vice-President of the Thai Red Cross Society has followed the footsteps of her fore-bears, carrying the noble humanitarian work they began, particularly the work of the Thai Red Cross society and the Faculty of Medicine, Chulalongkorn University. Her contributions have been a benefit to all, and she has earned great love and is held in high esteem by her people. Her ideas, thoughts, words, and activities have been of immense value to the faculty in both tangible and intangible ways. A selfless, dedicated women who is willing to make sacrifices for the common good, Her Royal Highness serves as a model humanitarian for the staff of the Faculty of Medicine, Chulalongkorn University, whose morale she has boosted and whose operations she has planned with the foresight ofa first-class administrator. Her devotion to the Thai Red Cross, and thus her devotion to her people, have indeed made her the royal gem within Thai hearts, with sparkling brilliance of her humanitarian deeds instilling the warmth of her love in our spirits.

History of King Chulalongkorn Memorial Hospital: 90 years anniversary.

The Thai Red Cross Society was founded by King Rama V (King Chulalongkorn) in 1893 (B.E. 2436) after an international conflict with France. The institute was originally called Saphaa Unaalom Daeng which was later named the Red Cross Society of Siam and did not get its permanent headquarters until 1914 in the reign of King Rama VI (King Vajiravudh) when Chulalongkorn Memorial Hospital was founded. It was the mandate of King Rama VI that the hospital is to be "most elegant, popular and marveled with the most modern medical equipments,..." the best hospital of the Orient, in order to be the most glorified memorial for King Chulalongkorn, the Father of King Rama VI. The hospital has been the leader in medical services, public health as well as medical science, and home to the Faculty of Medicine, Chulalongkorn University which has been the center of medical research at national and international levels.

Effects of ganglioside on paclitaxel (Taxol) induced neuropathy in rats.

The effects of ganglioside on paclitaxel induced neuropathy were studied in 15 female Wistar rats. The animals were equally divided into 3 groups based on the type of administrated drug. The first (C-group) received an intraperitoneal weekly injection of 1 ml of NSS for five weeks. The second (P-group) received 9 mg/kg of a paclitaxel intraperitoneal weekly injection for five weeks. The third (PG-group) received both ganglioside and paclitaxel. Sensory evaluation and electrophysiologic studies of the tail nerve were performed before the administration of the first dose and at the end of the experiment. Morphological evaluation of the sciatic nerve was also studied. The results revealed the mean reaction time of the tail flick test, latency, amplitude and nerve conduction velocity of the P-group in the first and seventh week were of significant difference. However, there was no significant difference detected in those of the C-group and the PG-group. There was significant difference in all parameters between the PG and P-groups but not between the PG and C-groups. Cross sections of the sciatic nerve in the P-group showed mild endoneurium edema and some degenerated axons. Small myelinated nerve fibers in the PG-group were prominent. The results of this study indicated that ganglioside treatment could produce some beneficial effects in an animal model of paclitaxel induced neuropathy.