ABSTRACT
Previous studies have suggested that hyperhomocysteinaemia [Hcy] could be a strong and independent cardiovascular risk factor. Many factors could influence the serum concentration of Hcy such as vitamin B 12, folic acid, renal failure, hypothyroId status, ovarian failure and cancers. So the aim of our study was to evaluate the prevalence of hyperhomocysteinaemia among 54 type 2 diabetic patients and to study, its relationship with vitamin B 12, folic acid and Metformin. Were excluded all patients with an evident cause of hyperhomocysteinaemia. Mean age of patients was 52.8 years. Mean Hcy was 11,7 + 6,9 micro mol/l. The prevalence of hyperhomocysteinaemia was 27,8% in our group. There were eight [14%] patients with vitamin B 12 deficiency and three among them had hyperhomocysteinaemia There was no folic acid deficiency and no relationship with Metformin treatment. We suggest a wide screening of hyperhomocysteinaemia in type 2 diabetic patients and folic acid or vitamin B 12 supplements if necessary