Use of artificial intelligence to predict response to neoadjuvant chemotherapy in breast cancer

:Breast cancer is the object of thousands of studies worldwide. Nevertheless, few tools are available to corroborate prediction of response to neoadjuvant chemotherapy. Artificial intelligence is being researched for its potential utility in several fields of knowledge, including oncology. The development of a standardized Artificial intelligence-based predictive model for patients with breast cancer may help make clinical management more personalized and effective. We aimed to apply Artificial intelligence models to predict the response to neoadjuvant chemotherapy based solely on clinical and pathological data. Methods: Medical records of 130 patients treated with neoadjuvant chemotherapy were reviewed and divided into two groups: 90 samples to train the network and 40 samples to perform prospective testingand validate the results obtained by the Artificial intelligence method. Results: Using clinicopathologic data alone, the artificial neural network was able to correctly predict pathologic complete response in 83.3% of the cases. It also correctly predicted 95.6% of locoregional recurrence, as well as correctly determined whether patients were alive or dead at a given time point in 90% of the time. To date, no published research has used clinicopathologic data to predict the response to neoadjuvant chemotherapy in patients with breast cancer, thus highlighting the importance of the present study. Conclusions: Artificial neural network may become an interesting tool for predicting response to neoadjuvant chemotherapy, locoregional recurrence, systemic disease progression, and survival in patients with breast cancer (AU)

Catheter-related infection due to Papiliotrema laurentii in an oncologic patient: Case report and systematic review

ABSTRACT Background: Papiliotrema laurentii is one of several non-neoformans cryptococci that have rarely been associated with human infection, since it was previously considered saprophyte and thought to be non-pathogenic to humans. Nevertheless, increasing number of reports of human infection have emerged in recent years, mostly in oncologic patients. Aim: To report a case of a female patient with pyloric obstructive cancer with a catheter-related Papiliotrema laurentii blood stream infection and systematically review the available evidence on P. laurentii infection in humans. Methods: Retrieval of studies was based on Medical Subject Headings and Health Sciences Descriptors, which were combined using Boolean operators. Searches were run on the electronic databases Scopus, Web of Science, MEDLINE (PubMed), BIREME (Biblioteca Regional de Medicina), LILACS (Latin American and Caribbean Health Sciences Literature), Cochrane Library for Systematic Reviews and Opengray.eu. There was no language or date of publication restrictions. The reference lists of the studies retrieved were searched manually. Results: The search strategy retrieved 1703 references. In the final analysis, 31 references were included, with the description of 35 cases. Every patient but one had a previous co-morbidity - 48.4 % of patients had a neoplasm. Amphotericin B was the most used treatment and only a single case of resistance to it was reported. Most patients were cured of the infection. Conclusion: P. laurentii infection in humans is usually associated to neoplasia and multiple co-morbidities, and amphotericin B seems to be a reliable agent for treatment.

Femoral stem-bone interface analysis of logical uncemented stem / Análise numérica do comportamento biomecânico da haste femoral não-cimentada Logical

This paper evaluates the mechanical behavior of an uncemented hip stem using finite element analysis. The analysis is focused on the stem-bone interaction which is assessed by simulation of distinct conditions encountered daily on orthopedic practice of hip implants. Logical uncemented femoral stem was used in this work. Three distinct conditions have been modeled: a) exposed neck with fully embedded fins, b) partially exposed anti-rotational fins and c) fully exposed fins, representing real femoral hip conditions. Anthropometric variations and different angulations for the stem neck were investigated for typical body weight of populations submitted to implants. The ratio of mobilized stress to yield stress is shown to be lower than 55% indicating a safety factor against stem failure. Although small displacements are observed in all conditions, the displacement increases with the increase of both the length of exposed fins and the magnitude of applied forces. Even for the extreme condition of fully exposed fins, the prostheses will support the working loads, and the risk of bone fracture still has a safety factor. Stresses and displacements change considerably with neck angulations suggesting that anthropometric variations should be considered in the future to optimize prostheses performance. Numerical analysis of the used uncemented femoral stem demonstrated that small stresses and strains are generated under working load conditions indicating that a proper factor of safety is obtained for the static conditions tested in the present study.

A presente pesquisa avalia o comportamento mecânico da haste femoral não-cimentada Logical através de elementos finitos. Foram analisadas diferentes condições de contorno encontradas na prática ortopédica: a) apenas o colo exposto; b) com as aletas anti-rotatórias parcialmente expostas; e c) com as aletas totalmente expostas. Variações antropométricas foram consideradas pelas diferentes angulações de colo propostas e através de diferentes cargas aplicadas. A haste apresentou um bom coeficiente de segurança. Embora pequenos deslocamentos sejam observados em todas as condições, existe um maior deslocamento com o aumento da exposição das aletas da prótese. Mesmo para a condição extrema com as aletas totalmente expostas, a prótese suporta as cargas de trabalho e ainda há um bom fator de segurança. Tensões e deslocamentos se modificam consideravelmente com as diferentes angulações propostas para o colo, sugerindo que as variações antropométricas devam ser consideradas no futuro para otimizar o desempenho da prótese.

Estresse ao osso em torno de implantes ortodônticos na região de molares inferiores: uma avaliação por elementos finitos / Stress to the bone around orthodontic implants in the mandibular molar region: a finite element evaluation

Mini-screw implants have been commonly used for orthodontic anchorage. However, the behavior of implants may vary according to their location, inclination, loading position and loading direction. The objective of this study was to apply finite element to analyze stress distribution around mini-implants inserted into the buccal cortical bone, in the inferior molar region, when a force of 3 N was applied, varying implant inclination and loading direction, also simulating immediate loading and osseointegration conditions. We carried out a threedimensional analysis of a human cadaveric mandible and of a 9 mm length, 1.5 mm diameter titanium implant. The implant model was introduced into the buccal cortical bone, between the first and second mandibular molars. Finite-element analysis of the implant-bone structure was carried out applying a constant force of 3 N at varying angles (15, 30, 45, 60, 75, and 90 degrees), and in five different positions along the bone surface axis (perpendicularly, vertically at ± 10 degrees, and horizontally at ± 20 degrees). Out of all combinations tested, stress affected only the cortical bone, not being intense enough to cause cortical bone resorption. Stress distribution varied slightly (8.55 to 38.74 Mpa) due to implant inclination and loading direction. Immediate loading generated greater tensions (12.70 to 38.74 Mpa) when compared to osseointegration (8.55 to 21.44 Mpa). A force of 3 N did not result in a tension that could cause cortical bone resorption. Immediate loading resulted in greater tensions to the bone, regardless of implant inclination and loading direction.

Mini-implantes têm sido utilizados para ancoragem ortodôntica e seu comportamento pode variar de acordo com a sua localização e inclinação, com a posição e a direção da carga aplicada. Este estudo analisou a distribuição de tensões ao osso em torno de mini-implantes inseridos no osso cortical na região de molares inferiores, quando uma carga de 3 N é aplicada, variando a inclinação do implante e a direção da força,assim como situações de carga imediata e osseointegração. Uma mandíbula humana e um implante de titânio com 9 mm de comprimento e 1,5mm de diâmetro foram modelados, com o implante introduzido na face vestibular entre o primeiro e o segundo molares. Este modelo foi analisado pelo método de elementos finitos aplicando força constante de 3N com angulagens de 15, 30, 45, 60 e 75 graus, com o implante perpendicular ao osso e com inclinação vertical de 10 graus e horizontal de 20 graus. Em todas as combinações testadas a tensão afetou apenas o osso cortical, porém não apresentou intensidade suficiente para resultar em reabsorção óssea. Sua distribuição variou (8,55 a 38,74 Mpa) em função da inclinação do implante e da direção da carga. A situação de carga imediata gerou maiores tensões (12,70 a 38.74 Mpa) quando comparada à osseointegração (8,55 a 21,44 Mpa). Conclui-se que uma força de 3N não resulta em tensão que possa causar reabsorção da cortical óssea e que a carga imediata produz maior tensão ao osso, independentemente da inclinação do implante e da direção da força.

Stresses in implant-supported overdentures with bone resorption: a 3-D finite element analysis / Tensões em sobredentaduras com reabsorção óssea: análise por elementos finitos tridimensional

PURPOSE: This 3D-finite elements method study evaluated the effect of bone resorption on the stress distribution in overdentures with bone loss surrounding implants and resorption of the distal ridge. METHODS: Tridimensional models were built from the images of a computerized tomography of a mandible and 3D laser digitalization of implants, abutments, mucosa, and complete denture. The geometric models of implants and abutments were mounted at the canine region to build reference model 1 - absence of bone resorption. To build the test models the mandible geometric solid was modified to simulate 2-mm vertical bone loss surrounding the implants (model 2) and resorption of the distal ridge (model 3). Finite elements models were generated, and a 100 N static load was applied at the first molar region of each model to compare the von Mises stress distributions in selected points. RESULTS: Von Mises stresses increased on the bone surrounding implants and on the prosthetic components in the model with 2-mm vertical bone loss. The combination of 2-mm vertical bone loss and resorption of the distal ridge did not increase the stresses compared with the model with only bone loss surrounding implants. The highest stress concentration at marginal bone and implants occurred on the same side of the vertical load application for all models. CONCLUSION: The results suggest that the bone loss surrounding implants increases stress concentration in dental implants, abutments, and marginal bone independently from the bone resorption of the distal ridge.

OBJETIVO: Avaliar, através da análise por elementos finitos com modelo tridimensional, o efeito da reabsorção óssea na distribuição de tensões em prótese tipo overdenture, em situações de perda óssea ao redor dos implantes e reabsorção do rebordo posterior. METODOLOGIA: Foram construídos modelos tridimensionais de uma mandíbula e de intermediários protéticos, prótese total, placa resiliente e implante. Os modelos geométricos dos implantes e intermediários protéticos foram montados na região dos caninos, constituindo o modelo 1. Para a construção dos modelos experimentais, o contorno do modelo geométrico da mandíbula foi alterado para simular a perda óssea nos implantes (modelo 2) e a reabsorção do rebordo posterior associada à perda óssea marginal nos implantes (modelo 3). Para gerar a malha de elementos finitos os materiais foram considerados homogêneos, isotrópicos e linearmente elásticos. Uma carga de 100 N foi aplicada indiretamente, sobre uma simulação de bolo alimentar, na região de primeiro molar inferior direito em cada um dos três modelos. Foram analisadas as distribuições de tensão de von Mises em pontos pré-determinados. RESULTADOS: A reabsorção óssea do rebordo posterior associada à perda óssea do osso periimplantar promoveu maior concentração de tensões nos implantes, nos componentes protéticos e no tecido ósseo marginal. Houve maior concentração de tensões no osso periimplantar e nos implantes no mesmo lado de aplicação da carga. CONCLUSÃO: Os resultados sugerem que a perda óssea periimplantar aumenta a concentração de tensões nos implantes, pilares e osso marginal independentemente da reabsorção óssea na crista distal.