ABSTRACT
The control of dyslipidemia using plants is an important subject of studies since it has numerous benefits in cardiovascular protection. The objective of this study was to evaluate the effect of three Camellia sinensis L. teas (green, red, and white) on left ventricular hypertrophy and insulin resistance in low-density lipoprotein receptor knockout (LDLr-/-) mice fed a high-fat diet. The LDLr-/- mice were divided into four experimental groups: Group C: standard feed; Group CT: standard feed and three teas, Group HL: high-fat feed; HLT Group: high-fat feed and three teas. The three types of tea (green, red, and white) originated from different processing of the Camellia sinensis L. plant, and were administered associated once a day at a dose of 25 mg/kg by gavage for 60 days. The teas partially prevented hyperlipidemia, the decrease of the serum levels of high-density lipoproteins (HDL), insulin resistance, and increased C-reactive protein (CRP) levels, and completely prevented left ventricular hypertrophy in LDLr -/- mice of the HLT group. In conclusion, the three Camellia sinensis L. teas used to control genetic dyslipidemia associated with a high-fat diet can be used as an auxiliary treatment associated with the control of lipid intake, thus promoting cardiac protection against hyperlipidemia.
Subject(s)
Animals , Male , Rabbits , Insulin Resistance , Plant Extracts/administration & dosage , Hypertrophy, Left Ventricular/drug therapy , Camellia sinensis/chemistry , Dyslipidemias/drug therapy , Antioxidants/administration & dosage , Tea , Antioxidants/isolation & purificationABSTRACT
O efeito hipotensor do verapamil foi estudado em animais normais e em portadores de dois modelos experimentais de hipertensao: hipertensao neurogenica aguda e hipertensao renal.Para o estudo foram utilizados ratos acordados, com o proposito de evitar a depressao produzida por anestesia, dos reflexos cardiovasculares que controlam a pressao arterial e a frequencia cardiaca. O verapamil foi injetado, por via venosa, em infusao continua por 30 minutos, nas doses de 4 a 22 ug/min/100g.Os resultados mostraram que a pressao arterial media diminui tanto nos animais normais como nos hipertensos, sendo a hipotensao mais rapida e intensa no grupo de ratos com hipertensao neurologica aguda.A frequencia cardiaca aumentou nos ratos normais e com hipertensao renal devido a hipotensao provocada pelo verapamil. Nos ratos com hipertensao neurogenica aguda, ocorreu bradicardia devido a inatividade dos pressoreceptores evidenciando a acao cronotropica negativa do verapamil. Os resultados obtidos recomendariam seu uso nas crises hipertensivas em pacientes sem depressao de reflexos cardiovasculares