ABSTRACT
Background The association of metabolic syndrome with the subclinical changes in the function and structure ofthe heart has been established clinically. Additionally, diastolic dysfunction and left ventricular hypertrophy werealso found to be closely associated with the metabolic syndrome. It has been identified in many of the previousstudies that LV dysfunction and LV hypertrophy are major risk factors of heart failure with preserved ejectionfraction.Aim The study was carried out to identify whether preclinical LV diastolic dysfunction can occur independent ofLV hypertrophy in MS or not.Methods 100 patients were taken for the study with 50 patients in the case group having MS and 50 patients inthe control group without MS. The patients who had any exiting cardiovascular disease including (heart failure,left ventricular ejection fraction [LVEF]<50%, coronary artery disease, or valvular heart disease were excluded fromthe study.Results The mean age of the case group was 45±8.5 years and that of the control group was 42±7.5 years therewas statistically significant difference among the various baseline characteristics between the case and controlgroups as the p value was found to be <0.05. All the ecocardioghraphic parameters had statistically significantdifference among the two groups except Left ventricular end diastolic dimension.Conclusion The study depicted a positive correlation between diastolic dysfunction and metabolic syndrome.Furthermore, it was observed in the study that metabolic syndrome proved to the baseline indicator of prognosisto diastolic dysfunction in the near future.
ABSTRACT
The study aims to assess the cardiovascular response to treadmill exercise test in healthy Indian adolescents. A group of 50 healthy adolescents took part in the study. Cardiovascular response was assessed by using treadmill exercise test as per Bruce protocol. Pulse rate, blood pressure and ECG were recorded before, during and after undertaking the treadmill test. Mean age and body mass index (BMI) were 18.7±0.51 yrs. and 21.4±3.44 kg/m2 respectively. Karl Pearson Correlation analysis showed highly significant negative correlation between BMI and exercise time (r = –0.598, P<0.001) and between resting DBP and Exercise Time (r = –0.424, P<0.002). While BMI and DBP showed highly significant positive correlation (r = 0.463, P<0.001). During exercise pulse and SBP rose and DBP fell. SBP rose from mean 122 to 175 (rise by 53 mm of Hg) and DBP fell from mean 78 to 65 (fall by 13 mm of Hg). One min recovery pulse was 156 indicating 22% fall from target heart rate. All the parameters returned to near resting value at 6 min recovery. In 30% students DBP showed exaggerated response i.e. rise during exercise. These students had more BMI and higher resting DBP as compared to other students, which could be the reason for exaggerated response in these participants. In ECG there were no significant ST/T changes during exercise or recovery period. This study provides normal data for small sample of healthy Indian adolescents when subjected to treadmill exercise test.