ABSTRACT
Effects of Physalis minima Linn (PML) methanolic extract on blood glucose level and sperm quality of normoglycaemic mice have been investigated. Twenty four ICR male mice were randomly assigned to four groups and fed with maintenance diets (commercial rat chow, 5 g/head/day and water ad-libitum). Group A (n=6) served as a control and received additional 2 ml/kg bodyweight (bwt) of distilled water. Group B, C and D were supplemented with 50, 100 and 200 mg/kg bwt of PML, respectively. Bodyweight and blood glucose level were monitored on a weekly basis. After four weeks of treatment, all animals were sacrificed by cervical dislocation and their epididymis was collected and subjected to sperm analysis. Bodyweight was increased (p<0.05) over time but no differences (p>0.05) were observed between treatments. Blood glucose was decreased significantly (p<0.05) in PML treated groups (dose dependent manner) compared to control. Sperm quality was not affected with PML supplementation. In conclusion, PML methanolic extract exhibit hypoglycaemic effect without affecting sperm quality in male mice.
ABSTRACT
Methanolic extract of Phaleria macrocarpa fruits was evaluated for the anti-hypertensive and anti-hyperglycaemic capacity. For a period of three weeks, 18 male young Spontaneous Hypertensive Rats (SHR) were divided into three experimental groups and received commercial rat pellets as their maintenance diet. At the same duration, SHR in Group 1 received 2 ml/kg/day of distilled water and served as a negative control. Meanwhile, SHR in Group 2 and Group 3 received 0.5 mg/kg/day of Telmisartan (positive control) and 500 mg/kg/day P. macrocarpa fruits methanolic extract, respectively. Bodyweight, arterial blood pressure and blood glucose were measured on a weekly basis. All SHR showed significant increased (p<0.05) in their bodyweight but did not differ significantly (p>0.05) between groups. Blood pressure and blood glucose significantly decreased (p<0.05) in SHR treated with Telmisartan and P. macrocarpa compared to negative control. These results lead us to conclude that P. macrocarpa fruits methanolic extract exhibit anti-hypertensive and anti-hyperglycaemic activities.