ABSTRACT
Objective To study expression and clinical significance of TGF-? 1 in the placenta of the patients with pregnancy-induced hypertension(PIH). Methods The SABC immunohistochemical method was performed to determine the location and intensity of TGF-? 1 expression in placental tissues of 64 patients with PIH and 20 normal pregnant women. Results TGF-? 1 expression was principally localized in the trophoblast and decidual cells. The expression level of TGF-? 1 in the trophoblasts and decidual cells significantly increased in the patients with PIH compared with the normal pregnant women, and elevated with the severity of PIH increased. A negative relation was found between the expression level of TGF-? 1 and the weight of placenta and neonate in the patients with PIH. Conclusion The elevated expression of TGF-? 1 in placenta leads to the deficiency of trophoblast cell invasion, which may be one of the pathogenic causes of PIH.
ABSTRACT
Objective To study the expression and clinical significance of transforming growth factor-beta1(TGF?1) and its receptors(TGF?RⅠ and TGF?RⅡ) in placentas of pregnancy-induced hypertension(PIH). Methods Immunohistochemistry (SABC) was used to determine the distribution and intensity of TGF?1,TGF?RⅠ,TGF?RⅡ staining in placentas of 64 cases of PIH patients (21, 20 and 23 of mild, moderate and severe cases, respectively) and 20 cases of normal gravidas. Results The expression of TGF?1,TGF?RⅠ and TGF?RⅡ in placental trophoblasts and decidual cells was significantly increased in PIH group compared with the normal group (TGF?1:70.31% vs 35.00%,P